An electrochemical biosensor for the detection of tuberculosis specific DNA with CRISPR-Cas12a and redox-probe modified oligonucleotide

An electrochemical biosensor for the detection of tuberculosis specific DNA with CRISPR-Cas12a and redox-probe modified oligonucleotide

Background: The development of a robust and accurate point-of-care platform for the detection of tuberculosis (TB) biomarkers is important for disease control. In the current study, the detection principle relies on the shredding of PES-modified non-specific ssDNA (Poly T) in the presence of target...

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Bibliographic Details
Main Authors: Saman Taufiq, Madoka Nagata, Shah Rukh Abbas, Koji Sode
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Tuberculosis
DNA IS6110
CRISPR-Cas12a
Redox-probe
Square wave voltammetry
Electrochemical biosensor
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024167850
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