Blockade of de novo dNTP biosynthesis pathway delays HIV-1 early life cycle kinetics and dynamics

Blockade of de novo dNTP biosynthesis pathway delays HIV-1 early life cycle kinetics and dynamics

ABSTRACT The early events of the HIV-1 life cycle, such as reverse transcription, and capsid shedding commonly known as uncoating, are interdependent and tightly regulated, enabling HIV-1 to adapt to diverse host cells. Here, we explored how host cell dNTP pool size modulates the kinetics and dynami...

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Main Authors: Mohammad Anwar Siddique, Michael D. McRaven, Muhammad Shoaib Arif, Edward J. Allen, Charia McKee, Shravya Honne, Tahmina Sultana, Baek Kim, Ann M. Carias, João I. Mamede, Thomas J. Hope
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
HIV-1
early life cycle
dNTPs
de novo dNTP biosynthesis pathway
ribonucleotide reductase (RNR)
Online Access:https://journals.asm.org/doi/10.1128/mbio.01047-25
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https://journals.asm.org/doi/10.1128/mbio.01047-25

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