Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS

Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS

Summary: Mutations in the Fused in Sarcoma (FUS) gene cause familial amyotrophic lateral sclerosis (ALS), characterized by selective degeneration of spinal motor neurons (sMNs) with relative sparing of cortical neurons (CNs). The mechanisms underlying this cell-type vulnerability remain unclear. Her...

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Main Authors: Barbara Szewczyk, Vitaly Zimyanin, Julia Japtok, Aaron Held, Arun Pal, Dajana Großmann, Hannes Glaß, Alexandra V. Jürs, Banaja P. Dash, Maciek Bak, Marcel Naumann, Christiane Hartmann, Olena Kuksenko, René Günther, Tzu-Ting Kao, Katrin Sameith, Andreas Dahl, Jared Sterneckert, Eleonora Aronica, Neil A. Shneider, Andreas Büttner, Alberto Catanese, Hemali Phatnani, Markus Kipp, Brian J. Wainger, Anand Goswami, Andreas Hermann
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008848
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http://www.sciencedirect.com/science/article/pii/S2211124725008848

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