Divergent androgen regulation of unfolded protein response pathways drives prostate cancer

Divergent androgen regulation of unfolded protein response pathways drives prostate cancer

Abstract The unfolded protein response (UPR) is a homeostatic mechanism to maintain endoplasmic reticulum (ER) function. The UPR is activated by various physiological conditions as well as in disease states, such as cancer. As androgens regulate secretion and development of the normal prostate and d...

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Main Authors: Xia Sheng, Yke Jildouw Arnoldussen, Margrethe Storm, Martina Tesikova, Hatice Zeynep Nenseth, Sen Zhao, Ladan Fazli, Paul Rennie, Bjørn Risberg, Håkon Wæhre, Håvard Danielsen, Ian G Mills, Yang Jin, Gökhan Hotamisligil, Fahri Saatcioglu
Format: Article
Language:English
Published: Springer Nature 2015-04-01
Series:EMBO Molecular Medicine
Subjects:
androgen receptor
androgens
ER stress
prostate cancer
UPR
Online Access:https://doi.org/10.15252/emmm.201404509
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https://doi.org/10.15252/emmm.201404509

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