Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment

Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment

Multiple findings underline a link between altered brain cholesterol metabolism and Alzheimer's disease (AD) pathogenesis. Physiologically, excess brain cholesterol is mainly converted into 24-hydroxycholesterol (24-OHC) by the neuron-specific enzyme CYP46A1. Of note, we previously observed in...

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Main Authors: Serena Giannelli, Francesca Eroli, Raúl Loera-Valencia, Valerio Leoni, Maria Latorre-Leal, Gabriella Testa, Erica Staurenghi, Barbara Sottero, Paola Gamba, Silvia Maioli, Gabriella Leonarduzzi
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Neurobiology of Disease
Subjects:
24-hydroxycholesterol
CYP46A1
Tau hyperphosphorylation
Tau oligomers
Dendritic arborization
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002451
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