Evaluating functional C1INH with multiple laboratory methods across Hereditary Angioedema types

Evaluating functional C1INH with multiple laboratory methods across Hereditary Angioedema types

IntroductionHereditary Angioedema (HAE) is a rare genetic disease characterized by recurrent episodes of edema and classified into HAE with C1 inhibitor deficiency (HAE-C1INH types 1 and 2) and HAE with normal C1INH (HAE-nC1INH). This study evaluates the function of C1 inhibitor (fC1INH) in patients...

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Main Authors: Maine Luellah Demaret Bardou, Rosemeire Navickas Constantino-Silva, Maria Luiza Oliva Alonso, Ana Júlia Ribeiro Teixeira, Pedro Francisco Giavina-Bianchi, Eli Mansour, João Bosco Pesquero, Solange Oliveira Rodrigues Valle, Anete Sevciovic Grumach
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
hereditary angioedema
C1 inhibitor
factor XII
complement C4
biomarker
diagnosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1654078/full
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