Pathological α-synuclein elicits granulovacuolar degeneration independent of tau

Pathological α-synuclein elicits granulovacuolar degeneration independent of tau

Abstract Background Pathologic heterogeneity is a hallmark of Lewy body dementia (LBD), yet the impact of Lewy pathology on co-pathologies is poorly understood. Lewy pathology, containing α-synuclein, is often associated with regional tau pathology burden in LBD. Similarly, granulovacuolar degenerat...

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Bibliographic Details
Main Authors: Dylan J. Dues, Madalynn L. Erb, Alysa Kasen, Naman Vatsa, Erin T. Williams, An Phu Tran Nguyen, Michael X. Henderson, Darren J. Moore
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Translational Neurodegeneration
Subjects:
Lewy pathology
Alpha-synuclein
Tau
Granulovacuolar degeneration
Protein aggregation
Neurodegeneration
Online Access:https://doi.org/10.1186/s40035-025-00494-5
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https://doi.org/10.1186/s40035-025-00494-5

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