Regulation of pattern recognition receptor signaling by palmitoylation
Summary: Pattern recognition receptors (PRRs), consisting of Toll-like receptors, RIG-I-like receptors, cytosolic DNA sensors, and NOD-like receptors, sense exogenous pathogenic molecules and endogenous damage signals to maintain physiological homeostasis. Upon activation, PRRs stimulate the sensiti...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224028943 |
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| author | Xiaocui Li Xiaofang Hu Hongjuan You Kuiyang Zheng Renxian Tang Fanyun Kong |
| author_facet | Xiaocui Li Xiaofang Hu Hongjuan You Kuiyang Zheng Renxian Tang Fanyun Kong |
| author_sort | Xiaocui Li |
| collection | DOAJ |
| description | Summary: Pattern recognition receptors (PRRs), consisting of Toll-like receptors, RIG-I-like receptors, cytosolic DNA sensors, and NOD-like receptors, sense exogenous pathogenic molecules and endogenous damage signals to maintain physiological homeostasis. Upon activation, PRRs stimulate the sensitization of nuclear factor κB, mitogen-activated protein kinase, TANK-binding kinase 1-interferon (IFN) regulatory factor, and inflammasome signaling pathways to produce inflammatory factors and IFNs to activate Janus kinase/signal transducer and activator of transcription signaling pathways, resulting in anti-infection, antitumor, and other specific immune responses. Palmitoylation is a crucial type of post-translational modification that reversibly alters the localization, stability, and biological activity of target molecules. Here, we discuss the available knowledge on the biological roles and underlying mechanisms linked to protein palmitoylation in modulating PRRs and their downstream signaling pathways under physiological and pathological conditions. Moreover, recent advances in the use of palmitoylation as an attractive therapeutic target for disorders caused by the dysregulation of PRRs were summarized. |
| format | Article |
| id | doaj-art-d282eb07167a4bbcb2e407cdf32b8aa6 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-d282eb07167a4bbcb2e407cdf32b8aa62025-01-13T04:19:04ZengElsevieriScience2589-00422025-02-01282111667Regulation of pattern recognition receptor signaling by palmitoylationXiaocui Li0Xiaofang Hu1Hongjuan You2Kuiyang Zheng3Renxian Tang4Fanyun Kong5Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Breast Surgery, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, ChinaJiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaJiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China; National Demonstration Center for Experimental Basic Medical Sciences Education, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaJiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China; National Demonstration Center for Experimental Basic Medical Sciences Education, Xuzhou Medical University, Xuzhou, Jiangsu, China; Corresponding authorJiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China; Corresponding authorSummary: Pattern recognition receptors (PRRs), consisting of Toll-like receptors, RIG-I-like receptors, cytosolic DNA sensors, and NOD-like receptors, sense exogenous pathogenic molecules and endogenous damage signals to maintain physiological homeostasis. Upon activation, PRRs stimulate the sensitization of nuclear factor κB, mitogen-activated protein kinase, TANK-binding kinase 1-interferon (IFN) regulatory factor, and inflammasome signaling pathways to produce inflammatory factors and IFNs to activate Janus kinase/signal transducer and activator of transcription signaling pathways, resulting in anti-infection, antitumor, and other specific immune responses. Palmitoylation is a crucial type of post-translational modification that reversibly alters the localization, stability, and biological activity of target molecules. Here, we discuss the available knowledge on the biological roles and underlying mechanisms linked to protein palmitoylation in modulating PRRs and their downstream signaling pathways under physiological and pathological conditions. Moreover, recent advances in the use of palmitoylation as an attractive therapeutic target for disorders caused by the dysregulation of PRRs were summarized.http://www.sciencedirect.com/science/article/pii/S2589004224028943Biological sciencesMolecular biologyImmune response |
| spellingShingle | Xiaocui Li Xiaofang Hu Hongjuan You Kuiyang Zheng Renxian Tang Fanyun Kong Regulation of pattern recognition receptor signaling by palmitoylation iScience Biological sciences Molecular biology Immune response |
| title | Regulation of pattern recognition receptor signaling by palmitoylation |
| title_full | Regulation of pattern recognition receptor signaling by palmitoylation |
| title_fullStr | Regulation of pattern recognition receptor signaling by palmitoylation |
| title_full_unstemmed | Regulation of pattern recognition receptor signaling by palmitoylation |
| title_short | Regulation of pattern recognition receptor signaling by palmitoylation |
| title_sort | regulation of pattern recognition receptor signaling by palmitoylation |
| topic | Biological sciences Molecular biology Immune response |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224028943 |
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