SLAMF8 and NINJ2 promote neuroinflammation and oxidative stress through TLR4 NF kappa B pathway in Alzheimer’s disease

SLAMF8 and NINJ2 promote neuroinflammation and oxidative stress through TLR4 NF kappa B pathway in Alzheimer’s disease

Abstract This study aimed to investigate the expression and role of Signaling Lymphocytic Activation Molecule Family Member 8 (SLAMF8) in Alzheimer’s disease (AD), particularly its interaction with NINJ2 in the TLR4/NF-κB signaling pathway. SLAMF8 expression levels in AD models were analyzed using t...

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Bibliographic Details
Main Authors: Shuo Liu, Yuze He, He Chen, Wenwen Zhao, Heman Xu, Tao Bai, Juan Feng
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease (AD)
SLAMF8
NINJ2
TLR4/NF-κB pathway
Neuroinflammation
Oxidative stress
Online Access:https://doi.org/10.1038/s41598-025-02097-6
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https://doi.org/10.1038/s41598-025-02097-6

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