Renal cell carcinoma risk associated with lower intake of micronutrients
Abstract Kidney cancer incidence in African Americans (AA) is higher than among European Americans (EA); reasons for this disparity are not fully known. Dietary micronutrients may have a protective effect on renal cell carcinoma (RCC) development by inhibiting oxidative DNA damage and tumor growth....
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-08-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.1639 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846114403661905920 |
|---|---|
| author | Cathryn H. Bock Julie J. Ruterbusch Andreana N. Holowatyj Susan E. Steck Alison L. Van Dyke Won Jin Ho Michele L. Cote Jonathan N. Hofmann Faith Davis Barry I. Graubard Kendra L. Schwartz Mark P. Purdue |
| author_facet | Cathryn H. Bock Julie J. Ruterbusch Andreana N. Holowatyj Susan E. Steck Alison L. Van Dyke Won Jin Ho Michele L. Cote Jonathan N. Hofmann Faith Davis Barry I. Graubard Kendra L. Schwartz Mark P. Purdue |
| author_sort | Cathryn H. Bock |
| collection | DOAJ |
| description | Abstract Kidney cancer incidence in African Americans (AA) is higher than among European Americans (EA); reasons for this disparity are not fully known. Dietary micronutrients may have a protective effect on renal cell carcinoma (RCC) development by inhibiting oxidative DNA damage and tumor growth. We evaluated whether any micronutrient associations differed by race in the US Kidney Cancer Study. 1142 EA and AA RCC cases and 1154 frequency‐matched controls were enrolled in a population‐based case‐control study between 2002 and 2007. Dietary micronutrient intake was derived from an interviewer‐administered diet history questionnaire. RCC risk associated with micronutrient intake was estimated using adjusted odds ratios from logistic regression comparing lower to highest quartiles of intake and sample weighting. Inverse associations with RCC risk were observed for α‐carotene, β‐carotene, lutein zeaxanthin, lycopene, vitamin A, folate, thiamin, vitamin C, α‐tocopherol, β‐tocopherol, γ‐tocopherol, and selenium. A trend for β‐cryptoxanthin was suggested among EA but not AA or the total sample (P‐interaction = .04). Otherwise, findings did not differ by race, gender, age, or smoking status. The increase in RCC risk associated with lower micronutrient intake is similar within AA and EA populations. A diet rich in sources of micronutrients found in fruits, vegetables, and nuts may help to reduce the overall risk of RCC. |
| format | Article |
| id | doaj-art-d1ee44d3ccf54eb6b7b898da49552eb7 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-d1ee44d3ccf54eb6b7b898da49552eb72024-12-20T13:15:45ZengWileyCancer Medicine2045-76342018-08-01784087409710.1002/cam4.1639Renal cell carcinoma risk associated with lower intake of micronutrientsCathryn H. Bock0Julie J. Ruterbusch1Andreana N. Holowatyj2Susan E. Steck3Alison L. Van Dyke4Won Jin Ho5Michele L. Cote6Jonathan N. Hofmann7Faith Davis8Barry I. Graubard9Kendra L. Schwartz10Mark P. Purdue11Karmanos Cancer Institute Wayne State University School of Medicine Detroit MI USAKarmanos Cancer Institute Wayne State University School of Medicine Detroit MI USADepartment of Population Health Sciences Huntsman Cancer Institute University of Utah Salt Lake City UT USAEpidemiology and Biostatistics The Cancer Prevention and Control Program Arnold School of Public Health University of South Carolina Columbia SC USADivision of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USADepartment of Oncology Sidney Kimmel Comprehensive Cancer Center Johns Hopkins School of Medicine Baltimore MD USAKarmanos Cancer Institute Wayne State University School of Medicine Detroit MI USADivision of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USASchool of Public Health University of Alberta Edmonton AB CanadaDivision of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USAKarmanos Cancer Institute Wayne State University School of Medicine Detroit MI USADivision of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USAAbstract Kidney cancer incidence in African Americans (AA) is higher than among European Americans (EA); reasons for this disparity are not fully known. Dietary micronutrients may have a protective effect on renal cell carcinoma (RCC) development by inhibiting oxidative DNA damage and tumor growth. We evaluated whether any micronutrient associations differed by race in the US Kidney Cancer Study. 1142 EA and AA RCC cases and 1154 frequency‐matched controls were enrolled in a population‐based case‐control study between 2002 and 2007. Dietary micronutrient intake was derived from an interviewer‐administered diet history questionnaire. RCC risk associated with micronutrient intake was estimated using adjusted odds ratios from logistic regression comparing lower to highest quartiles of intake and sample weighting. Inverse associations with RCC risk were observed for α‐carotene, β‐carotene, lutein zeaxanthin, lycopene, vitamin A, folate, thiamin, vitamin C, α‐tocopherol, β‐tocopherol, γ‐tocopherol, and selenium. A trend for β‐cryptoxanthin was suggested among EA but not AA or the total sample (P‐interaction = .04). Otherwise, findings did not differ by race, gender, age, or smoking status. The increase in RCC risk associated with lower micronutrient intake is similar within AA and EA populations. A diet rich in sources of micronutrients found in fruits, vegetables, and nuts may help to reduce the overall risk of RCC.https://doi.org/10.1002/cam4.1639African Americanscarcinomadietmicronutrientsrenal cellvitamins |
| spellingShingle | Cathryn H. Bock Julie J. Ruterbusch Andreana N. Holowatyj Susan E. Steck Alison L. Van Dyke Won Jin Ho Michele L. Cote Jonathan N. Hofmann Faith Davis Barry I. Graubard Kendra L. Schwartz Mark P. Purdue Renal cell carcinoma risk associated with lower intake of micronutrients Cancer Medicine African Americans carcinoma diet micronutrients renal cell vitamins |
| title | Renal cell carcinoma risk associated with lower intake of micronutrients |
| title_full | Renal cell carcinoma risk associated with lower intake of micronutrients |
| title_fullStr | Renal cell carcinoma risk associated with lower intake of micronutrients |
| title_full_unstemmed | Renal cell carcinoma risk associated with lower intake of micronutrients |
| title_short | Renal cell carcinoma risk associated with lower intake of micronutrients |
| title_sort | renal cell carcinoma risk associated with lower intake of micronutrients |
| topic | African Americans carcinoma diet micronutrients renal cell vitamins |
| url | https://doi.org/10.1002/cam4.1639 |
| work_keys_str_mv | AT cathrynhbock renalcellcarcinomariskassociatedwithlowerintakeofmicronutrients AT juliejruterbusch renalcellcarcinomariskassociatedwithlowerintakeofmicronutrients AT andreananholowatyj renalcellcarcinomariskassociatedwithlowerintakeofmicronutrients AT susanesteck renalcellcarcinomariskassociatedwithlowerintakeofmicronutrients AT alisonlvandyke renalcellcarcinomariskassociatedwithlowerintakeofmicronutrients AT wonjinho renalcellcarcinomariskassociatedwithlowerintakeofmicronutrients AT michelelcote renalcellcarcinomariskassociatedwithlowerintakeofmicronutrients AT jonathannhofmann renalcellcarcinomariskassociatedwithlowerintakeofmicronutrients AT faithdavis renalcellcarcinomariskassociatedwithlowerintakeofmicronutrients AT barryigraubard renalcellcarcinomariskassociatedwithlowerintakeofmicronutrients AT kendralschwartz renalcellcarcinomariskassociatedwithlowerintakeofmicronutrients AT markppurdue renalcellcarcinomariskassociatedwithlowerintakeofmicronutrients |