Development of a General Composite Scale (GENCOMS) for Progressive Neurodegenerative Diseases and Implications for the Assessment of Disease-Modifying Therapies

Development of a General Composite Scale (GENCOMS) for Progressive Neurodegenerative Diseases and Implications for the Assessment of Disease-Modifying Therapies

Abstract Introduction The reliable assessment of treatment outcomes for disease-modifying therapies (DMT) in neurodegenerative disease is challenging. The objective of this paper is to describe a generalized framework for developing composite scales that can be applied in diverse, degenerative condi...

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Bibliographic Details
Main Authors: Samuel P. Dickson, Craig H. Mallinckrodt, Basia Rogula, Lauren C. Powell, Michele H. Potashman, Vladimir Coric, Gilbert J. L’Italien, Suzanne B. Hendrix
Format: Article
Language:English
Published: Adis, Springer Healthcare 2024-09-01
Series:Neurology and Therapy
Subjects:
Composite measure
Neurodegenerative disease
Disease progression
Functional impairment
Partial least squares regression
Online Access:https://doi.org/10.1007/s40120-024-00661-2
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https://doi.org/10.1007/s40120-024-00661-2

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