TXNIP promotes viral replication by disrupting MAVS-mediated antiviral signaling and serves as a therapeutic target for antiviral therapy

TXNIP promotes viral replication by disrupting MAVS-mediated antiviral signaling and serves as a therapeutic target for antiviral therapy

Thioredoxin-interacting protein (TXNIP) is a multifunctional regulator involved in oxidative stress, inflammation, and glucose metabolism. In this study, we investigated the role of TXNIP in viral infection and its potential as a therapeutic target. Our findings reveal that HSV-1 infection induces T...

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Bibliographic Details
Main Authors: Ruilin Chen, Wenyu Wu, Jiajia Han, Qiyun Lei, Jiawan Chen, Dan Guo, Chan Wang, Xiaodong Tang, Min Zou, Shuwen Liu, Xingang Yao
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
TXNIP
HSV-1
MAVS
Luteolin
innate immune response
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002691
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