Drug repurposing for Alzheimer’s disease using a graph-of-thoughts based large language model to infer drug-disease relationships in a comprehensive knowledge graph

Drug repurposing for Alzheimer’s disease using a graph-of-thoughts based large language model to infer drug-disease relationships in a comprehensive knowledge graph

Abstract Drug repurposing (DR) offers a promising alternative to the high cost and low success rate of traditional drug development, especially for complex diseases like Alzheimer’s disease (AD). This study addressed DR for AD from three key angles: (1) demonstrating how disease-specific knowledge g...

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Main Authors: Zhiping Paul Wang, Xi Li, Nicholas Matsumoto, Mythreye Venkatesan, Jui-Hsuan Chang, Jay Moran, Hyunjun Choi, Binglan Li, Yufei Meng, Miguel E. Hernandez, Jason H. Moore
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BioData Mining
Online Access:https://doi.org/10.1186/s13040-025-00466-5
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https://doi.org/10.1186/s13040-025-00466-5

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