Therapeutic benefits of glycerol in dry eye disease
Dry eye disease (DED) is one of the most commonly diagnosed eye disorders, with a prevalence ranging from 5 to 50%, depending on the geographic location. DED is a multifactorial disorder of the tears and ocular surface, which results in symptoms of discomfort, visual disturbance, and tear film insta...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1531670/full |
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| author | Victoria Ronderos Wendy B. Bollag Wendy B. Bollag Wendy B. Bollag |
| author_facet | Victoria Ronderos Wendy B. Bollag Wendy B. Bollag Wendy B. Bollag |
| author_sort | Victoria Ronderos |
| collection | DOAJ |
| description | Dry eye disease (DED) is one of the most commonly diagnosed eye disorders, with a prevalence ranging from 5 to 50%, depending on the geographic location. DED is a multifactorial disorder of the tears and ocular surface, which results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is also accompanied by increased osmolarity of the tear film and inflammation of the surface of the eye. Multiple therapeutic agents have been used to treat DED, with glycerol emerging as a promising component of ophthalmic preparations, due to its humectant, lubricant, demulcent, and osmoprotective properties. This review aims to evaluate the current evidence concerning the therapeutic benefits of glycerol in managing DED, focusing on its possible mechanisms of action, clinical efficacy, and potential advantages over other treatments. |
| format | Article |
| id | doaj-art-d189630a11ea4230a84d244543b31ae5 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-d189630a11ea4230a84d244543b31ae52025-01-15T05:10:23ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15316701531670Therapeutic benefits of glycerol in dry eye diseaseVictoria Ronderos0Wendy B. Bollag1Wendy B. Bollag2Wendy B. Bollag3Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, United StatesDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, United StatesCharlie Norwood VA Medical Center, Augusta, GA, United StatesJames and Jean Culver Vision Discovery Institute, Medical College of Georgia at Augusta University, Augusta, GA, United StatesDry eye disease (DED) is one of the most commonly diagnosed eye disorders, with a prevalence ranging from 5 to 50%, depending on the geographic location. DED is a multifactorial disorder of the tears and ocular surface, which results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is also accompanied by increased osmolarity of the tear film and inflammation of the surface of the eye. Multiple therapeutic agents have been used to treat DED, with glycerol emerging as a promising component of ophthalmic preparations, due to its humectant, lubricant, demulcent, and osmoprotective properties. This review aims to evaluate the current evidence concerning the therapeutic benefits of glycerol in managing DED, focusing on its possible mechanisms of action, clinical efficacy, and potential advantages over other treatments.https://www.frontiersin.org/articles/10.3389/fmed.2024.1531670/fullcorneadry eye diseaseglyceringlycerolinflammationphosphatidylglycerol |
| spellingShingle | Victoria Ronderos Wendy B. Bollag Wendy B. Bollag Wendy B. Bollag Therapeutic benefits of glycerol in dry eye disease Frontiers in Medicine cornea dry eye disease glycerin glycerol inflammation phosphatidylglycerol |
| title | Therapeutic benefits of glycerol in dry eye disease |
| title_full | Therapeutic benefits of glycerol in dry eye disease |
| title_fullStr | Therapeutic benefits of glycerol in dry eye disease |
| title_full_unstemmed | Therapeutic benefits of glycerol in dry eye disease |
| title_short | Therapeutic benefits of glycerol in dry eye disease |
| title_sort | therapeutic benefits of glycerol in dry eye disease |
| topic | cornea dry eye disease glycerin glycerol inflammation phosphatidylglycerol |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1531670/full |
| work_keys_str_mv | AT victoriaronderos therapeuticbenefitsofglycerolindryeyedisease AT wendybbollag therapeuticbenefitsofglycerolindryeyedisease AT wendybbollag therapeuticbenefitsofglycerolindryeyedisease AT wendybbollag therapeuticbenefitsofglycerolindryeyedisease |