Human Pluripotent Stem Cell‐Derived Skeletal Muscle Organoid Model of Aging‐Induced Sarcopenia

Human Pluripotent Stem Cell‐Derived Skeletal Muscle Organoid Model of Aging‐Induced Sarcopenia

ABSTRACT Background Sarcopenia is defined by the age‐related loss of muscle mass and function, with an impaired regenerative capacity of satellite cells (SCs). Despite their recognized importance in muscle regeneration, human model‐based studies on SCs in sarcopenia are still lacking, limiting our u...

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Main Authors: Seongjun Park, Min‐Kyoung Shin, Dong Seok Jeong, Xin Yi Yeo, Yeo Jin Kim, Junaid Muhammad, Minju Kim, Seongeun Gu, Jeoung Eun Lee, Yunjin Park, Su Bin Lim, Ji Young Mun, Sangyong Jung, Dong Ryul Lee, Junghyun Jo
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
aging
human pluripotent stem cell
human skeletal muscle organoid
sarcopenia
satellite cell
testosterone
Online Access:https://doi.org/10.1002/jcsm.70045
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https://doi.org/10.1002/jcsm.70045

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