Prevalence of hemoglobinopathies among Malayali tribes of Jawadhu hills, Tiruvannamalai district, Tamil Nadu, India: a community-based cross-sectional study
Background Hemoglobin (Hb), a red pigment of red blood cells (RBCs), carries oxygen from the lungs to different organs of the body and transports carbon dioxide back to the lungs. Any fault present in the Hb structure leads to undesirable functional effects of the RBCs, such as sickle cell anemia (S...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2024.2350320 |
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| author | Balasubramanian Ganesh Thangarasu Rajakumar Subhendu Kumar Acharya Shanmugasundaram Devika Venkatachalam Ramachandran Jayaram Yuvaraj Anita Nadkarni Shanmugam Rajasubramaniam Harpreet Kaur |
| author_facet | Balasubramanian Ganesh Thangarasu Rajakumar Subhendu Kumar Acharya Shanmugasundaram Devika Venkatachalam Ramachandran Jayaram Yuvaraj Anita Nadkarni Shanmugam Rajasubramaniam Harpreet Kaur |
| author_sort | Balasubramanian Ganesh |
| collection | DOAJ |
| description | Background Hemoglobin (Hb), a red pigment of red blood cells (RBCs), carries oxygen from the lungs to different organs of the body and transports carbon dioxide back to the lungs. Any fault present in the Hb structure leads to undesirable functional effects of the RBCs, such as sickle cell anemia (SCA), thalassemia, etc. Hemoglobinopathies affect around 7% of people in both developed and developing countries globally. The aim of the present study was to determine the prevalence and carrier frequencies of hemoglobinopathies including SCA, thalassemia, and other abnormal Hb variants among Malayali tribes in the Jawadhu hills of Tiruvannamalai district, Tamil Nadu, India.Methods A community-based cross-sectional study was carried out among 443 Malayali tribes inhabiting the Jawadhu hills of Tiruvannamalai district from July 2022 to September 2022. The RBC indices were analyzed using an automated 5-part hematology analyzer (Mindray, BC-5150) and hemoglobin fractions were done using the HPLC system (Bio-Rad, D-10) following standard protocols.Findings A total of 443 participants were screened, out of whom 14.67% had an abnormal Hb fraction, 83.30% were identified as normal, and 2.03% were borderline. Notably, the study revealed a prevalence of 0.68% for the α-thalassemia trait and 13.99% for the β-thalassemia trait.Interpretation Haemoglobinopathies, specifically the β-thalassemia trait, were most prevalent among the Malayali tribal population of Tamil Nadu residing in the Jawadhu hills of Tiruvannamalai district. Hence, we need special attention for creating awareness, increasing hemoglobinopathies screening programs, and improving the importance of tribal health conditions by the government and non-governmental organizations (NGOs) for the betterment of the ethnic tribes. |
| format | Article |
| id | doaj-art-d136d54e3b8443379e5ffba43c7da300 |
| institution | Kabale University |
| issn | 1607-8454 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj-art-d136d54e3b8443379e5ffba43c7da3002024-12-12T15:08:53ZengTaylor & Francis GroupHematology1607-84542024-12-0129110.1080/16078454.2024.2350320Prevalence of hemoglobinopathies among Malayali tribes of Jawadhu hills, Tiruvannamalai district, Tamil Nadu, India: a community-based cross-sectional studyBalasubramanian Ganesh0Thangarasu Rajakumar1Subhendu Kumar Acharya2Shanmugasundaram Devika3Venkatachalam Ramachandran4Jayaram Yuvaraj5Anita Nadkarni6Shanmugam Rajasubramaniam7Harpreet Kaur8ICMR-National Institute of Epidemiology (ICMR-NIE), Chennai, IndiaICMR-National Institute of Epidemiology (ICMR-NIE), Chennai, IndiaICMR-Regional Medical Research Centre (ICMR-RMRC), Odisha, IndiaICMR-National Institute of Epidemiology (ICMR-NIE), Chennai, IndiaICMR-National Institute of Epidemiology (ICMR-NIE), Chennai, IndiaICMR-National Institute of Epidemiology (ICMR-NIE), Chennai, IndiaICMR-National Institute of Immunohaematology (ICMR-NIIH), Mumbai, IndiaICMR-National Institute of Research in Tribal Health (ICMR-NIRTH), Jabalpur, IndiaIndian Council of Medical Research (ICMR), New Delhi, IndiaBackground Hemoglobin (Hb), a red pigment of red blood cells (RBCs), carries oxygen from the lungs to different organs of the body and transports carbon dioxide back to the lungs. Any fault present in the Hb structure leads to undesirable functional effects of the RBCs, such as sickle cell anemia (SCA), thalassemia, etc. Hemoglobinopathies affect around 7% of people in both developed and developing countries globally. The aim of the present study was to determine the prevalence and carrier frequencies of hemoglobinopathies including SCA, thalassemia, and other abnormal Hb variants among Malayali tribes in the Jawadhu hills of Tiruvannamalai district, Tamil Nadu, India.Methods A community-based cross-sectional study was carried out among 443 Malayali tribes inhabiting the Jawadhu hills of Tiruvannamalai district from July 2022 to September 2022. The RBC indices were analyzed using an automated 5-part hematology analyzer (Mindray, BC-5150) and hemoglobin fractions were done using the HPLC system (Bio-Rad, D-10) following standard protocols.Findings A total of 443 participants were screened, out of whom 14.67% had an abnormal Hb fraction, 83.30% were identified as normal, and 2.03% were borderline. Notably, the study revealed a prevalence of 0.68% for the α-thalassemia trait and 13.99% for the β-thalassemia trait.Interpretation Haemoglobinopathies, specifically the β-thalassemia trait, were most prevalent among the Malayali tribal population of Tamil Nadu residing in the Jawadhu hills of Tiruvannamalai district. Hence, we need special attention for creating awareness, increasing hemoglobinopathies screening programs, and improving the importance of tribal health conditions by the government and non-governmental organizations (NGOs) for the betterment of the ethnic tribes.https://www.tandfonline.com/doi/10.1080/16078454.2024.2350320HemoglobinopathiesthalassemiaMalayali tribesJawadhu HillsTamil NaduIndia |
| spellingShingle | Balasubramanian Ganesh Thangarasu Rajakumar Subhendu Kumar Acharya Shanmugasundaram Devika Venkatachalam Ramachandran Jayaram Yuvaraj Anita Nadkarni Shanmugam Rajasubramaniam Harpreet Kaur Prevalence of hemoglobinopathies among Malayali tribes of Jawadhu hills, Tiruvannamalai district, Tamil Nadu, India: a community-based cross-sectional study Hematology Hemoglobinopathies thalassemia Malayali tribes Jawadhu Hills Tamil Nadu India |
| title | Prevalence of hemoglobinopathies among Malayali tribes of Jawadhu hills, Tiruvannamalai district, Tamil Nadu, India: a community-based cross-sectional study |
| title_full | Prevalence of hemoglobinopathies among Malayali tribes of Jawadhu hills, Tiruvannamalai district, Tamil Nadu, India: a community-based cross-sectional study |
| title_fullStr | Prevalence of hemoglobinopathies among Malayali tribes of Jawadhu hills, Tiruvannamalai district, Tamil Nadu, India: a community-based cross-sectional study |
| title_full_unstemmed | Prevalence of hemoglobinopathies among Malayali tribes of Jawadhu hills, Tiruvannamalai district, Tamil Nadu, India: a community-based cross-sectional study |
| title_short | Prevalence of hemoglobinopathies among Malayali tribes of Jawadhu hills, Tiruvannamalai district, Tamil Nadu, India: a community-based cross-sectional study |
| title_sort | prevalence of hemoglobinopathies among malayali tribes of jawadhu hills tiruvannamalai district tamil nadu india a community based cross sectional study |
| topic | Hemoglobinopathies thalassemia Malayali tribes Jawadhu Hills Tamil Nadu India |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2024.2350320 |
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