Bioactive Cyclopeptide Alkaloids and Ceanothane Triterpenoids from <i>Ziziphus mauritiana</i> Roots: Antiplasmodial Activity, UHPLC-MS/MS Molecular Networking, ADMET Profiling, and Target Prediction

Bioactive Cyclopeptide Alkaloids and Ceanothane Triterpenoids from <i>Ziziphus mauritiana</i> Roots: Antiplasmodial Activity, UHPLC-MS/MS Molecular Networking, ADMET Profiling, and Target Prediction

Malaria continues to pose a significant global health burden, driving the search for novel antimalarial agents to address emerging drug resistance. This study evaluated the antiplasmodial potential of <i>Ziziphus mauritiana</i> Lam. (Rhamnaceae) roots through an integrated phytochemical...

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Main Authors: Sylvestre Saidou Tsila, Mc Jesus Kinyok, Joseph Eric Mbasso Tameko, Bel Youssouf G. Mountessou, Kevine Johanne Jumeta Dongmo, Jean Koffi Garba, Noella Molisa Efange, Lawrence Ayong, Yannick Stéphane Fotsing Fongang, Jean Jules Kezetas Bankeu, Norbert Sewald, Bruno Ndjakou Lenta
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
<i>Ziziphus mauritiana</i>
cyclopeptide alkaloids
ceanothane triterpenoids
antiplasmodial activity
in silico pharmacology
ADMET profiling
Online Access:https://www.mdpi.com/1420-3049/30/14/2958
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