Revealing the structural microenvironment of high metastatic risk uveal melanomas following decellularisation

Revealing the structural microenvironment of high metastatic risk uveal melanomas following decellularisation

Abstract Uveal melanoma (UM) is a rare aggressive intraocular tumour that spreads most commonly to the liver in tumours with loss of one copy of chromosome 3 (HR-M3); current treatments for metastatic disease remain largely ineffective. Pre-clinical research is increasingly using three-dimensional m...

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Bibliographic Details
Main Authors: Karen Aughton, Joshua Hattersley, Sarah E Coupland, Helen Kalirai
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Uveal melanoma
Tumour microenvironment
Extracellular matrix
Proteomics
Metastatic risk
Decellularisation
Online Access:https://doi.org/10.1038/s41598-024-78171-2
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https://doi.org/10.1038/s41598-024-78171-2

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