Lactylation modulation identifies key biomarkers and therapeutic targets in KMT2A-rearranged AML

Lactylation modulation identifies key biomarkers and therapeutic targets in KMT2A-rearranged AML

Abstract Acute Myeloid Leukemia (AML) with KMT2A rearrangements (KMT2Ar), found on chromosome 11q23, is often called KMT2A-rearranged AML (KMT2Ar-AML). This variant is highly aggressive, characterized by rapid disease progression and poor outcomes. Growing knowledge of epigenetic changes, especially...

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Bibliographic Details
Main Authors: Dan Liu, Silu Liu, Yujie Ji, Ziyan Jin, Zhewei He, Mengjia Hou, Dongyang Li, Xiao Ma
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Acute myeloid leukemia
KMT2A rearrangements (KMT2Ar)
Lactylation
Epigenetics
Machine learning
Online Access:https://doi.org/10.1038/s41598-025-86136-2
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