Expanding the therapeutic horizon in acute myeloid leukemia: The role of phosphoinositide-3-kinase-γ inhibition

Expanding the therapeutic horizon in acute myeloid leukemia: The role of phosphoinositide-3-kinase-γ inhibition

Acute myeloid leukemia (AML) remains a formidable challenge due to its high relapse rate and limited therapeutic options. This study investigates the role of phosphoinositide-3-kinase-γ (PI3Kγ) in AML and explores the therapeutic potential of the PI3Kγ inhibitor, eganelisib, in preclinical models. U...

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Bibliographic Details
Main Authors: Soumyajit Das, Mahendra Pratap Singh, Nishant Rai, Sanjit Sah
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:Iraqi Journal of Hematology
Subjects:
acute myeloid leukemia
crispr screening
eganelisib
phosphoinositide-3-kinase-γ
inhibition
treatment synergy
Online Access:https://journals.lww.com/10.4103/ijh.ijh_87_24
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https://journals.lww.com/10.4103/ijh.ijh_87_24

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