FUT8 upregulates CD36 and its core fucosylation to accelerate pericyte-myofibroblast transition through the mitochondrial-dependent apoptosis pathway during AKI-CKD

FUT8 upregulates CD36 and its core fucosylation to accelerate pericyte-myofibroblast transition through the mitochondrial-dependent apoptosis pathway during AKI-CKD

Abstract Background Activation of pericytes leads to renal interstitial fibrosis, but the regulatory mechanism of pericytes in the progression from AKI to CKD remains poorly understood. CD36 activation plays a role in the progression of CKD. However, the significance of CD36 during AKI-CKD, especial...

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Bibliographic Details
Main Authors: Yaxi Shang, Ziran Wang, Fan Yang, Weidong Wang, Qingzhu Tang, Xianan Guo, Xiangning Du, Xu Zhang, Jiaojiao Hao, Hongli Lin
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Medicine
Subjects:
AKI-CKD
Core fucosylation
CD36
FUT8
Pericyte
Online Access:https://doi.org/10.1186/s10020-024-00994-6
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https://doi.org/10.1186/s10020-024-00994-6

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