Sensory nerve EP4 facilitates heterotopic ossification by regulating angiogenesis-coupled bone formation

Sensory nerve EP4 facilitates heterotopic ossification by regulating angiogenesis-coupled bone formation

Objective: Heterotopic ossification (HO) refers to the abnormal development of bone in soft tissue rather than within bone itself. Previous research has shown that sensory nerve prostaglandin E2 receptor 4 (EP4) signaling not only governs pain perception but also influences bone formation. However,...

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Main Authors: Rongmin Lin, Hancheng Lin, Chencheng Zhu, Jieming Zeng, Jiahui Hou, Ting Xu, Yihui Tan, Xuyou Zhou, Yuan Ma, Mankai Yang, Kuanhai Wei, Bin Yu, Hangtian Wu, Zhuang Cui
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Orthopaedic Translation
Subjects:
Angiogenesis
Efnb2
EP4
Heterotopic ossification
Sensory nerve
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X24001219
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