Paromomycin targets HDAC1-mediated SUMOylation and IGF1R translocation in glioblastoma

Paromomycin targets HDAC1-mediated SUMOylation and IGF1R translocation in glioblastoma

ObjectiveThis study investigates the effects of Paromomycin on SUMOylation-related pathways in glioblastoma (GBM), specifically targeting HDAC1 inhibition.MethodsUsing TCGA and GTEx datasets, we identified SUMOylation-related genes associated with GBM prognosis. Molecular docking analysis suggested...

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Bibliographic Details
Main Authors: Zhong Min, Yuejie Guo, Luo Ning
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
glioblastoma multiforme
Paromomycin
HDAC1
SUMOylation
IGF1R
drug screening
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1490878/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1490878/full

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