Non-canonical ALK7 pathways promote pancreatic cancer metastasis through β-catenin/MMP-mediated basement membrane breakdown and intravasation

Non-canonical ALK7 pathways promote pancreatic cancer metastasis through β-catenin/MMP-mediated basement membrane breakdown and intravasation

Abstract Breaching the vascular barrier is a critical step in pancreatic ductal adenocarcinoma (PDAC) metastasis, yet the mechanisms enabling this process remain incompletely understood. Transforming growth factor beta (TGFβ) receptors have been extensively studied in many cancer types. However, act...

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Main Authors: Anna M. Kolarzyk, Yujin Kwon, Elizabeth Oh, Keng-Jung Lee, Su-Yeon Cho, Issahy Cano, Renhao Lu, Tae Joon Kwak, Jaehyun Lee, Gigi Wong, Andrew H. Kim, Omar Gandarilla, Manuel Hidalgo, Won Kyu Kim, Esak Lee
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Cancer
Subjects:
Pancreatic cancer
ALK7
Matrix metalloproteinases
Organ-on-a-chip
Intravasation
Online Access:https://doi.org/10.1186/s12943-025-02384-w
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https://doi.org/10.1186/s12943-025-02384-w

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