Factors associated with thermal injury of abdominal skin in focused ultrasound ablation of uterine fibroids
Objective To investigate the factors which may cause thermal injury of abdominal skin in patients with uterine fibroids (UFs) who underwent ultrasound-guided focused ultrasound ablation surgery (FUAS).Method A total of 123 patients were enrolled in the injury group. In contrast, 246 patients without...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2023.2295232 |
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| author | Tang Chendian Huang Guohua Zhibiao Wang Liu Fang Shuang Luo Xiaofang Liu Qiuling Shi |
| author_facet | Tang Chendian Huang Guohua Zhibiao Wang Liu Fang Shuang Luo Xiaofang Liu Qiuling Shi |
| author_sort | Tang Chendian |
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| description | Objective To investigate the factors which may cause thermal injury of abdominal skin in patients with uterine fibroids (UFs) who underwent ultrasound-guided focused ultrasound ablation surgery (FUAS).Method A total of 123 patients were enrolled in the injury group. In contrast, 246 patients without thermal injury were assigned to the non-injury group. The relationship between patient and treatment parameters and injury were explored using univariate analysis and multiple logistic regression analyses. In addition, the factors influencing the degree of thermal injury were analyzed using Kruskal–Wallis H.Results (1) Abdominal scars (p = .007, OR = 2.187, 95% CI: 1.242–3.849), abdominal wall thickness (p < .001, OR = 1.042, 95% CI: 1.019–1.067), fundus fibroids (p = .038, OR = 1.790, 95% CI: 1.033–3.100), UFs with hyperintense/mixed T2-weighted imaging (T2WI) signals (p = .022, OR = 1.843, 95% CI: 1.091–3.115), average sonication power (AP) (p = .025, OR = 1.021, 95% CI: 1.003–1.039), and treatment time (TT) (p < .001, OR = 1.017, 95% CI: 1.011–1.023) were independent risk factors for thermal injury, while treatment volume (TV) (p = .002, OR = 0.775, 95% CI: 0.661–0.909) was a protective factor for injury. (2) Four groups were subdivided according to the degree of thermal injury(Group A: without skin injury. Group B: with changed T2WI signal in the abdominal wall, Group C: mild skin injury, Group D: severe skin injury), comparison of each with every other showed that the abdominal wall in Groups A and D was thinner than Groups B and C, with statistically significant differences (PAB<0.05, PAC<0.01, PDC<0.05, PDB<0.05); Group A was slightly thicker than D, however, without statistical difference. The ratio of sonication time (ST) to TV in Group A was the lowest of all (PAB, PAC, PAD all < 0.05). And as the level of thermal injury rose, the ratio gradually increased, however, without statistical difference.Conclusions Based on our limited results, the following conclusion was made. (1) Abdominal scars, abdominal wall thickness, fundus fibroids, UFs with T2WI hyperintense/mixed signals, AP and TT were independent risk factor. (2) Neither too thick nor too thin abdominal walls would be recommended, as both might increase the risk of skin injury. (3) Noticeably, the risk of skin injury might increase considerably when the ST was longer and the sonication area was more fixed. |
| format | Article |
| id | doaj-art-cfaf69038b1c43c084e9c74b6b92981b |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
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| publishDate | 2024-12-01 |
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| series | International Journal of Hyperthermia |
| spelling | doaj-art-cfaf69038b1c43c084e9c74b6b92981b2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2023.2295232Factors associated with thermal injury of abdominal skin in focused ultrasound ablation of uterine fibroidsTang Chendian0Huang Guohua1Zhibiao Wang2Liu Fang3Shuang Luo4Xiaofang Liu5Qiuling Shi6State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Obstetrics and Gynecology, Suining Central Hospital, Suining, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Obstetrics and Gynecology, Suining Central Hospital, Suining, ChinaDepartment of Obstetrics and Gynecology, Suining Central Hospital, Suining, ChinaDepartment of Obstetrics and Gynecology, Suining Central Hospital, Suining, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaObjective To investigate the factors which may cause thermal injury of abdominal skin in patients with uterine fibroids (UFs) who underwent ultrasound-guided focused ultrasound ablation surgery (FUAS).Method A total of 123 patients were enrolled in the injury group. In contrast, 246 patients without thermal injury were assigned to the non-injury group. The relationship between patient and treatment parameters and injury were explored using univariate analysis and multiple logistic regression analyses. In addition, the factors influencing the degree of thermal injury were analyzed using Kruskal–Wallis H.Results (1) Abdominal scars (p = .007, OR = 2.187, 95% CI: 1.242–3.849), abdominal wall thickness (p < .001, OR = 1.042, 95% CI: 1.019–1.067), fundus fibroids (p = .038, OR = 1.790, 95% CI: 1.033–3.100), UFs with hyperintense/mixed T2-weighted imaging (T2WI) signals (p = .022, OR = 1.843, 95% CI: 1.091–3.115), average sonication power (AP) (p = .025, OR = 1.021, 95% CI: 1.003–1.039), and treatment time (TT) (p < .001, OR = 1.017, 95% CI: 1.011–1.023) were independent risk factors for thermal injury, while treatment volume (TV) (p = .002, OR = 0.775, 95% CI: 0.661–0.909) was a protective factor for injury. (2) Four groups were subdivided according to the degree of thermal injury(Group A: without skin injury. Group B: with changed T2WI signal in the abdominal wall, Group C: mild skin injury, Group D: severe skin injury), comparison of each with every other showed that the abdominal wall in Groups A and D was thinner than Groups B and C, with statistically significant differences (PAB<0.05, PAC<0.01, PDC<0.05, PDB<0.05); Group A was slightly thicker than D, however, without statistical difference. The ratio of sonication time (ST) to TV in Group A was the lowest of all (PAB, PAC, PAD all < 0.05). And as the level of thermal injury rose, the ratio gradually increased, however, without statistical difference.Conclusions Based on our limited results, the following conclusion was made. (1) Abdominal scars, abdominal wall thickness, fundus fibroids, UFs with T2WI hyperintense/mixed signals, AP and TT were independent risk factor. (2) Neither too thick nor too thin abdominal walls would be recommended, as both might increase the risk of skin injury. (3) Noticeably, the risk of skin injury might increase considerably when the ST was longer and the sonication area was more fixed.https://www.tandfonline.com/doi/10.1080/02656736.2023.2295232Focused ultrasound ablation surgeryuterine fibroidadverse effectthermal injuryskin |
| spellingShingle | Tang Chendian Huang Guohua Zhibiao Wang Liu Fang Shuang Luo Xiaofang Liu Qiuling Shi Factors associated with thermal injury of abdominal skin in focused ultrasound ablation of uterine fibroids International Journal of Hyperthermia Focused ultrasound ablation surgery uterine fibroid adverse effect thermal injury skin |
| title | Factors associated with thermal injury of abdominal skin in focused ultrasound ablation of uterine fibroids |
| title_full | Factors associated with thermal injury of abdominal skin in focused ultrasound ablation of uterine fibroids |
| title_fullStr | Factors associated with thermal injury of abdominal skin in focused ultrasound ablation of uterine fibroids |
| title_full_unstemmed | Factors associated with thermal injury of abdominal skin in focused ultrasound ablation of uterine fibroids |
| title_short | Factors associated with thermal injury of abdominal skin in focused ultrasound ablation of uterine fibroids |
| title_sort | factors associated with thermal injury of abdominal skin in focused ultrasound ablation of uterine fibroids |
| topic | Focused ultrasound ablation surgery uterine fibroid adverse effect thermal injury skin |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2023.2295232 |
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