PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS‐driven ELR+ CXC chemokine expression

PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS‐driven ELR+ CXC chemokine expression

Abstract The pathological retinal angiogenesis often causes blindness. Current anti‐angiogenic therapy for proliferative retinopathy targets the vascular endothelial growth factor (VEGF), but many patients do not radically benefit from this therapy. Herein, we report that circulating prostaglandin (...

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Main Authors: Yan Zhao, Yi Lei, Huying Ning, Yaqiang Zhang, Guilin Chen, Chenchen Wang, Qiangyou Wan, Shumin Guo, Qian Liu, Ruotian Xie, Yujuan Zhuo, Shuai Yan, Jing Zhao, Fengjiang Wei, Lu Wang, Xiaohong Wang, Weidong Li, Hua Yan, Ying Yu
Format: Article
Language:English
Published: Springer Nature 2022-12-01
Series:EMBO Molecular Medicine
Subjects:
anti‐angiogenic therapy
pathological retinal angiogenesis
PGF2α
Online Access:https://doi.org/10.15252/emmm.202216373
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https://doi.org/10.15252/emmm.202216373

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