PIEZO1 activity promotes stemness in mesenchymal stem cells under shear stress and enhances protection of leukemia cells

Abstract Mesenchymal stem cells (MSCs) differentiate into cells of multiple lineages and play an essential role in bone formation, tissue regeneration, immunomodulation and are also necessary to maintain hematopoiesis in bone marrow. The lineage commitment of MSCs into osteoblasts is controlled by s...

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Bibliographic Details
Main Authors: Amit Sharma, Jina Bhattacharyya, Piruthivi Sukumar, Bithiah Grace Jaganathan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-09549-z
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