Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia
Abstract Background Maternal agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AAs) have been implicated in the pathophysiology of preeclampsia, but their presence in their offsprings and their possible neonatal effects have not been specifically explored. This prospective stu...
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BMC
2025-01-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-024-07102-w |
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| author | Laure Ponthier Chahrazed El Hamel Perrine Coste Mazeau Sophie Martinez Sarah Wehbe Rachel Froget Catherine Yardin Vincent Guigonis |
| author_facet | Laure Ponthier Chahrazed El Hamel Perrine Coste Mazeau Sophie Martinez Sarah Wehbe Rachel Froget Catherine Yardin Vincent Guigonis |
| author_sort | Laure Ponthier |
| collection | DOAJ |
| description | Abstract Background Maternal agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AAs) have been implicated in the pathophysiology of preeclampsia, but their presence in their offsprings and their possible neonatal effects have not been specifically explored. This prospective study aimed to evaluate the presence of AT1-AAs and their potential clinical effects in neonates of AT1-AAs positive mothers. Methods Women with preeclampsia and their neonates were included. Blood samples were collected in order to search for AT1-AAs. Results AT1-AA determination was positive in 35 out of 64 of the studied women (54.7%). Thirty one newborns from the group of AT1-AA positive women were included and 22 (71%) were AT1-AA positive. The mothers’ and children’s AT1-AAs titers were significantly correlated. The 33 newborns from the group of AT1-AA negative women were all negative for AT1-AAs. Regarding the clinical data of newborns (birth weight, percentile of weight, gestational age, Apgar score at five minutes, mechanical or noninvasive ventilation), no significant difference was observed between the children with or without detected AT1-AAs. Conclusion Even though AT1-AAs are detected in newborns of positive mothers during the first days of life, no specific clinical signs seem to be associated with the presence of these antibodies. |
| format | Article |
| id | doaj-art-cf7f0674947b4daa8b3a30aec2cd928c |
| institution | Kabale University |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-cf7f0674947b4daa8b3a30aec2cd928c2025-01-05T12:49:29ZengBMCBMC Pregnancy and Childbirth1471-23932025-01-0125111010.1186/s12884-024-07102-wAngiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsiaLaure Ponthier0Chahrazed El Hamel1Perrine Coste Mazeau2Sophie Martinez3Sarah Wehbe4Rachel Froget5Catherine Yardin6Vincent Guigonis7Collection Biologique de L’Hôpital de La Mère Et de L’Enfant CB-HME (Mother and Child Biobank), University Hospital CenterCollection Biologique de L’Hôpital de La Mère Et de L’Enfant CB-HME (Mother and Child Biobank), University Hospital CenterDepartment of Obstetric Gynecology, University Hospital CenterDepartment of Obstetric Gynecology, University Hospital CenterDepartment of Obstetric Gynecology, University Hospital CenterDepartment of Pediatrics, University Hospital CenterCollection Biologique de L’Hôpital de La Mère Et de L’Enfant CB-HME (Mother and Child Biobank), University Hospital CenterCollection Biologique de L’Hôpital de La Mère Et de L’Enfant CB-HME (Mother and Child Biobank), University Hospital CenterAbstract Background Maternal agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AAs) have been implicated in the pathophysiology of preeclampsia, but their presence in their offsprings and their possible neonatal effects have not been specifically explored. This prospective study aimed to evaluate the presence of AT1-AAs and their potential clinical effects in neonates of AT1-AAs positive mothers. Methods Women with preeclampsia and their neonates were included. Blood samples were collected in order to search for AT1-AAs. Results AT1-AA determination was positive in 35 out of 64 of the studied women (54.7%). Thirty one newborns from the group of AT1-AA positive women were included and 22 (71%) were AT1-AA positive. The mothers’ and children’s AT1-AAs titers were significantly correlated. The 33 newborns from the group of AT1-AA negative women were all negative for AT1-AAs. Regarding the clinical data of newborns (birth weight, percentile of weight, gestational age, Apgar score at five minutes, mechanical or noninvasive ventilation), no significant difference was observed between the children with or without detected AT1-AAs. Conclusion Even though AT1-AAs are detected in newborns of positive mothers during the first days of life, no specific clinical signs seem to be associated with the presence of these antibodies.https://doi.org/10.1186/s12884-024-07102-wPreeclampsiaAT1-AAMothersNewbornsClinical data |
| spellingShingle | Laure Ponthier Chahrazed El Hamel Perrine Coste Mazeau Sophie Martinez Sarah Wehbe Rachel Froget Catherine Yardin Vincent Guigonis Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia BMC Pregnancy and Childbirth Preeclampsia AT1-AA Mothers Newborns Clinical data |
| title | Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia |
| title_full | Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia |
| title_fullStr | Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia |
| title_full_unstemmed | Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia |
| title_short | Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia |
| title_sort | angiotensin ii type 1 receptor autoantibodies and effects in neonates of women with preeclampsia |
| topic | Preeclampsia AT1-AA Mothers Newborns Clinical data |
| url | https://doi.org/10.1186/s12884-024-07102-w |
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