Unique pharmacological properties of etrasimod among S1P receptor modulators

Unique pharmacological properties of etrasimod among S1P receptor modulators

Etrasimod (ADP334) is an oral, once‐daily, selective sphingosine 1‐phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis and in development for the treatment of immune‐mediated inflammatory diseases. Interaction between S1P and its five recepto...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ibragim Gaidarov, H. Kiyomi Komori, Dariusz T. Stepniak, Karin Bruinsma, Huong Dang, Xiaohua Chen, Todd Anthony, Joel Gatlin, Lisa Karimi‐Naser, Anh‐Tuan Ton, Tim Indersmitten, Paul E. Miller, Andre Ghetti, Najah Abi‐Gerges, David Unett, Hussien Al‐Shamma, Christopher J. Rabbat, Catherine Crosby, John W. Adams
Format:	Article
Language:	English
Published:	Wiley 2025-01-01
Series:	FEBS Open Bio
Subjects:	etrasimod pharmacodynamics pharmacokinetics sphingosine 1‐phosphate receptor modulator
Online Access:	https://doi.org/10.1002/2211-5463.13907
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib
by: Jing Zhang, et al.
Published: (2025-01-01)

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy
by: Lin Wang, et al.
Published: (2025-02-01)

Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates
by: Yangyang Gao, et al.
Published: (2025-01-01)

Lysosphingolipids in ceramide-deficient skin lipid models
by: Georgios Paraskevopoulos, et al.
Published: (2025-01-01)

Siponimod supports remyelination in the non-supportive environment
by: Johann Krüger, et al.
Published: (2025-02-01)

Clinical presentation and management challenges of sphingosine-1-phosphate lyase insufficiency syndrome associated with an SGPL1 variant: a case report
by: Vahid Saeedi, et al.
Published: (2025-01-01)

Modeling the endocrine control of vitellogenin production in female rainbow trout
by: Kaitlin Sundling, et al.
Published: (2013-12-01)

Pimobendan oral solution is bioequivalent to pimobendan chewable tablets in beagle dogs
by: Olaf Kuhlmann, et al.
Published: (2025-01-01)

The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin—A Randomized, Controlled, Crossover Study
by: Liva K. Stuhr, et al.
Published: (2025-01-01)

How does chronic pain lead to memory loss?
by: Suelen Pereira, et al.
Published: (2025-01-01)

Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism
by: Rocio Diaz Escarcega, et al.
Published: (2025-01-01)

The Clinical Pharmacokinetics and Pharmacodynamics of Glimepiride—A Systematic Review and Meta-Analysis
by: Mubara Azhar, et al.
Published: (2025-01-01)

Antenatal corticosteroids in Singapore: a clinical and scientific assessment
by: Arundhati Gosavi, et al.
Published: (2024-09-01)

A Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in Healthy Adult Subjects
by: Lee HW, et al.
Published: (2025-01-01)

Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats.
by: Kalange, Muhamudu, et al.
Published: (2023)

Pharmacodynamic characteristics and influencing factors of tapentadol for chronic pain relief under dose titration
by: Liang Xin, et al.
Published: (2025-01-01)

Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies
by: Armin Sepp, et al.
Published: (2024-12-01)

Risk Factors and Patterns of Drug‐Drug Interactions in Two Categories of Level‐3 Hospitals in Dhaka: A Cross‐Sectional Study
by: Md. Abdus Samadd, et al.
Published: (2025-01-01)

Pharmacodynamics of Qingxuan Jiangya Decoction on Blood Pressure Control and Suppression of Cardiac and Renal Vascular Injury in Spontaneously Hypertensive Rats
by: Hongwei CHEN, et al.
Published: (2017-04-01)

Choosing the Right Angiotensin Converting Enzyme Inhibitors; Gender –Specific Approach
by: Neena Elsa Varghese, et al.
Published: (2024-12-01)

stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments
by: Roberto Visintainer, et al.
Published: (2025-01-01)

Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway
by: Zihan Song, et al.
Published: (2025-02-01)

Promising role of voxelotor in managing sickle cell disease in children: a narrative review
by: Amit Agrawal, et al.
Published: (2025-02-01)

Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies
by: Amani M. El Sisi, et al.
Published: (2025-01-01)

The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology
by: Abraham Tonny Hagan, et al.
Published: (2025-01-01)

Kinetic-pharmacodynamic model to predict post-rituximab B-cell repletion as a predictor of relapse in pediatric idiopathic nephrotic syndrome
by: Ziwei Li, et al.
Published: (2025-01-01)

Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease
by: Jingyun Wu, et al.
Published: (2025-01-01)

Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simulation
by: Xiao-Chen Wei, et al.
Published: (2025-01-01)

PK/PD-Guided Strategies for Appropriate Antibiotic Use in the Era of Antimicrobial Resistance
by: Tetsushu Onita, et al.
Published: (2025-01-01)

Population Pharmacokinetic–Pharmacodynamic Modeling of Granulocyte Colony‐Stimulating Factor to Optimize Dosing and Timing for CD34+ Cell Harvesting
by: Xu Jiang, et al.
Published: (2025-01-01)

Volume-regulated anion channels conduct ATP in undifferentiated mammary cells and promote tumorigenesis in xenograft nude mouse
by: Kishio Furuya, et al.
Published: (2025-01-01)

The compensatory enrichment of sphingosine-1-phosphate on HDL in FSGS enhances the protective function of glomerular endothelial cells compared to MCD
by: Yunfeng Xiong, et al.
Published: (2025-01-01)

Data-based regression models for predicting remifentanil pharmacokinetics
by: Prathvi Shenoy, et al.
Published: (2024-12-01)

A mathematical model for antibiotic control of bacteria in peritoneal dialysis associated peritonitis
by: Colette Calmelet, et al.
Published: (2014-08-01)

Effect of prophylactic doses of enoxaparin on antifactor Xa activity confirmed by rotational thromboelastometry in critically ill patients: a preliminary prospective cohort study
by: Piotr F. Czempik, et al.
Published: (2025-01-01)

A new strategy for pharmacodynamic substance screening and research on gut microbiota pathway mechanisms based on UPLC-Q-orbitrap-MS and 16S rRNA
by: Zhiying Yu, et al.
Published: (2025-01-01)

Cardiovascular events observed among patients in the etrasimod clinical programme: an integrated safety analysis of patients with moderately to severely active ulcerative colitis
by: Xiang Guo, et al.
Published: (2025-01-01)

Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies
by: Apolline Lefèvre, et al.
Published: (2025-01-01)

Shuangshen Granules Suppress Myeloid-derived Suppressor Cell-mediated Lung Premetastatic Niche Development by Targeting Sphingosine-1-Phosphate Receptor-1/Signal Transducer, Activator of Transcription 3 Signaling
by: Rui Liu, et al.
Published: (2024-12-01)

The spectrum-efficacy correlation of Kai-Xin-San for cognition of Aβ42 transgenic Drosophila and verification of its active ingredients
by: Jinfu Wu, et al.
Published: (2025-01-01)