Prunus mume derived extracellular vesicle-like particles alleviate experimental colitis via disrupting NEK7-NLRP3 interaction and inflammasome activation

Prunus mume derived extracellular vesicle-like particles alleviate experimental colitis via disrupting NEK7-NLRP3 interaction and inflammasome activation

Abstract Edible plant derived extracellular vesicle-like particles (EVLPs) have garnered attention as potential therapeutic agents for chronic inflammatory diseases. Prunus mume (PM) is a functional fruit known for its gastrointestinal benefits, yet the detail material basis and potential mechanism...

Full description

Saved in:

Bibliographic Details
Main Authors:	Qi Lv, Hongqiong Yang, Ying Xie, Xinjie Huang, Zhiqi Yan, Yingshan Lv, Yifan Cui, Lihong Hu, Hongzhi Qiao
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Journal of Nanobiotechnology
Subjects:	PM-EVLPs Ulcerative colitis NLRP3 inflammasome NEK7-NLRP3 interaction miR159
Online Access:	https://doi.org/10.1186/s12951-025-03567-9
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria
by: Mateusz Szczerba, et al.
Published: (2025-05-01)

Research progress on NLRP3 inflammasome regulation of periodontitis
by: LI Xuejing, et al.
Published: (2024-02-01)

The NLRP3 inflammasome in urogenital cancers: structure, dual function, and therapeutic potential
by: Weiming Sun, et al.
Published: (2025-07-01)

Verteporfin attenuates NLRP3 inflammasome activation to alleviate gout arthritis flares
by: Daniel C. Shippy, et al.
Published: (2025-07-01)

Shikonin inhibits NLRP3 inflammasome activation and controls inflammatory disease
by: Jing Huang, et al.
Published: (2025-05-01)

NLRP3 inflammasome in the pathogenesis of acute myocardial infarction: a cardiologist's view
by: V. V. Ryabov, et al.
Published: (2024-05-01)

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome
by: Jian Cui, et al.
Published: (2025-07-01)

Dihydromyricetin mitigates epilepsy and cognitive impairment via NLRP3 inhibition in rats
by: Qing Li, et al.
Published: (2025-04-01)

Roles of Inflammasome and Cytokines in the Pathogenesis of Autoimmune Thyroiditis
by: Gülten Ateş, et al.
Published: (2025-03-01)

Molecular hydrogen mitigates traumatic brain injury-induced lung injury via NLRP3 inflammasome inhibition
by: Lingling Liu, et al.
Published: (2025-05-01)

Blue light induces corneal epithelial damage by activating the NLRP3 inflammasome pathway
by: Jiayun Ge, et al.
Published: (2025-09-01)

Angiogenin Ameliorates Endometritis by Inhibiting NLRP3 Inflammasome Activation
by: Jiangxue Cai, et al.
Published: (2025-07-01)

NOX2/NLRP3-Inflammasome-Dependent Microglia Activation Promotes As(III)-Induced Learning and Memory Impairments in Developmental Rats
by: Linlin Zhang, et al.
Published: (2025-06-01)

Naringin mitigates experimental autoimmune prostatitis by modulating oxidative stress and the NLRP3 inflammasome via the PPAR-γ/NF-κB pathway
by: Wang Zhou, et al.
Published: (2025-07-01)

Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice
by: Dilpreet Kour, et al.
Published: (2025-03-01)

NLRP3 deficiency abrogates silica-induced neutrophil infiltration, pulmonary damage and fibrosis
by: Maggie Lam, et al.
Published: (2025-03-01)

Thiram-induced ER stress promotes mitochondrial calcium signaling and NLRP3 inflammasome activation in a tissue specific manner
by: Shah Nawaz, et al.
Published: (2025-03-01)

Mechanisms of NLRP3 inflammasome in pathogenesis and progression of inflammation-related gastrointestinal diseases
by: Fengmei Liu, et al.
Published: (2025-08-01)

Activation of spinal PGC-1α regulates microglial polarization through a feedback loop between ROS-mediated mitochondrial dysfunction and the NLRP3 inflammasome in neuropathic pain
by: Yanhua Chen, et al.
Published: (2025-07-01)

Integrative multi-omic analysis of NLRP3 inflammasome dysregulation and subtyping for personalized treatment in acute myeloid leukemia
by: Hong Zhang, et al.
Published: (2025-07-01)

NLRP3 Inflammasome — a new universal target of asymptomatic hyperuricemia and gout management
by: P. A. Lebedev, et al.
Published: (2024-07-01)

The protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of NLRP3 inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells
by: Peng Jiao, et al.
Published: (2020-01-01)

Osteoarthritis: modern aspects of pathogenesis, focus on low-intensity inflammation
by: I. S. Svintsitskaya, et al.
Published: (2025-04-01)

Effect of puerarin administration on serum NOD-like receptor protein 3 (NLRP3) inflammasome, C1Q/TNF-related protein 3 (CTRP3) and lipoprotein-associated phospholipase 2 (LP-PLA2) levels
by: Wang Ge, et al.
Published: (2025-01-01)

Microglial NFAT5 aggravates neuroinflammation via mediating NLRP6 inflammasome in experimental ischemic stroke
by: Hui Gan, et al.
Published: (2025-11-01)

Transcription factor EB improves hypoxic pulmonary hypertension in fetal rats by suppressing NLRP3 inflammasome activation via induction of mitophagy
by: Chaohong Chen, et al.
Published: (2025-07-01)

Ouabain alleviates Mycobacterium abscessus-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization
by: Nan Li, et al.
Published: (2025-08-01)

Ginsenoside Re ameliorates thioacetamide-induced acute liver injury through inhibiting autophagy-NLRP3 inflammasome pathway
by: Jing Lin, et al.
Published: (2025-06-01)

Activation of HTR2B Suppresses Osteosarcoma Progression through the STAT1‐NLRP3 Inflammasome Pathway and Promotes OASL1+ Macrophage Production to Enhance Antitumor Immunity
by: Zhen Huang, et al.
Published: (2025-08-01)

Nrf2/Nlrp3 signaling in aging BMSCs: Traf6 intervention as a novel approach to osteoporosis treatment
by: Yajun Li, et al.
Published: (2025-10-01)

ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury
by: Yan Bai, et al.
Published: (2025-04-01)

Sophora moocroftiana seeds ethanol extract regulates NLRP3 inflammasome activation and pyroptosis via ROS/TXNIP pathway to amelioration of NAFLD in vitro and in vivo
by: Ruiying Yuan, et al.
Published: (2025-08-01)

Case Report: A heterozygous mutation of NLRP3 in a Chinese child with NLRP3-AID
by: Yangming Ruan, et al.
Published: (2025-08-01)

Protective effect of TNF-α inhibitor on diabetic nephropathy in rats
by: HOU Jia-sheng, et al.
Published: (2019-01-01)

A phosphoproteomic study uncovers the importance of PP2A-B56α in liver injury precipitated by NLRP3 activation during MC-LR exposure
by: Haimeng Yin, et al.
Published: (2025-09-01)

Protein regulatory network mediated by palmitoylation modifications in the pathological progression of Parkinson’s disease: a narrative review
by: Jingjing Liu, et al.
Published: (2025-07-01)

METTL3 promotes podocyte pyroptosis in diabetic nephropathy through N6-methyladenosine modification of TRIM29 mRNA
by: Xiaohong Xu, et al.
Published: (2025-12-01)

Time- and dose-dependent activation of the NLRP3 and MyD88/NF-κB pathways by Trueperella pyogenes membrane vesicles in bovine endometrial epithelial cells
by: Dengfu Li, et al.
Published: (2025-07-01)

Macrophage NLRP3-dependent IL-1β production contributes to aortic fibrosis in heart failure with preserved ejection fraction
by: Chen Sheng, et al.
Published: (2024-12-01)

Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment
by: Jie Wang, et al.
Published: (2025-08-01)