Prunus mume derived extracellular vesicle-like particles alleviate experimental colitis via disrupting NEK7-NLRP3 interaction and inflammasome activation

Prunus mume derived extracellular vesicle-like particles alleviate experimental colitis via disrupting NEK7-NLRP3 interaction and inflammasome activation

Abstract Edible plant derived extracellular vesicle-like particles (EVLPs) have garnered attention as potential therapeutic agents for chronic inflammatory diseases. Prunus mume (PM) is a functional fruit known for its gastrointestinal benefits, yet the detail material basis and potential mechanism...

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Bibliographic Details
Main Authors: Qi Lv, Hongqiong Yang, Ying Xie, Xinjie Huang, Zhiqi Yan, Yingshan Lv, Yifan Cui, Lihong Hu, Hongzhi Qiao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
PM-EVLPs
Ulcerative colitis
NLRP3 inflammasome
NEK7-NLRP3 interaction
miR159
Online Access:https://doi.org/10.1186/s12951-025-03567-9
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https://doi.org/10.1186/s12951-025-03567-9

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