Long-Term Time in Target Range for Systolic Blood Pressure Since Childhood and Midlife Arterial Stiffness
Background: Elevated blood pressure (BP) in childhood is associated with adult hypertension and arterial stiffness. However, the effect of long-term time in target range (TTR) for BP since childhood on the risk of arterial stiffness in midlife remains unclear. Objectives: The purpose of this study w...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772374724004563 |
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| author | Yang Wang, MD, PhD Han Qi, PhD Hao Jia, MD Dan Wang, MD Yue Sun, MD Bo-Wen Zhang, MPH Ming-Fei Du, MD Gui-Lin Hu, MD Zi-Yue Man, MD Chao Chu, MD, PhD Xiao-Jun Yang, MPH Teng Zhang, MD Tong-Shuai Guo, MD Xi Zhang, MD Yu Yan, MD Zheng Liu, PhD Ming-Ke Chang, MD Hao Li, MD Fang-Yao Chen, PhD Yu-Ming Kang, PhD Jie Ren, MD Zu-Yi Yuan, MD, PhD Ling Zhang, PhD Jian-Jun Mu, MD |
| author_facet | Yang Wang, MD, PhD Han Qi, PhD Hao Jia, MD Dan Wang, MD Yue Sun, MD Bo-Wen Zhang, MPH Ming-Fei Du, MD Gui-Lin Hu, MD Zi-Yue Man, MD Chao Chu, MD, PhD Xiao-Jun Yang, MPH Teng Zhang, MD Tong-Shuai Guo, MD Xi Zhang, MD Yu Yan, MD Zheng Liu, PhD Ming-Ke Chang, MD Hao Li, MD Fang-Yao Chen, PhD Yu-Ming Kang, PhD Jie Ren, MD Zu-Yi Yuan, MD, PhD Ling Zhang, PhD Jian-Jun Mu, MD |
| author_sort | Yang Wang, MD, PhD |
| collection | DOAJ |
| description | Background: Elevated blood pressure (BP) in childhood is associated with adult hypertension and arterial stiffness. However, the effect of long-term time in target range (TTR) for BP since childhood on the risk of arterial stiffness in midlife remains unclear. Objectives: The purpose of this study was to determine the independent association of TTR for systolic blood pressure (SBP) from childhood to midlife with arterial stiffness in adulthood. Methods: This study used data from the ongoing cohort of the Hanzhong Adolescent Hypertension Study. SBP-TTR was assessed over 36 years, with the target ranges of SBP defined as the 90th to 95th percentile of SBP for age, sex, and height in childhood, and 110 to 130 mm Hg in adulthood. Arterial stiffness was defined as brachial-ankle pulse wave velocity >1,400 cm/s. Results: Of the total 1,959 participants, 55.5% (1,088 of 1,959) were men, and the mean age was 49 years. The risk of arterial stiffness exhibited a gradual decrease with increasing SBP-TTR over the 36-year follow-up. Compared with the participants in the lowest quartile of SBP-TTR from childhood to midlife, those in the highest quartile showed significantly reduced arterial stiffness risk in midlife. This association persisted even after adjusting for mean SBP and SBP variability. Furthermore, men in the highest quartile of SBP-TTR demonstrated a markedly lower arterial stiffness risk than those in the lowest quartile, whereas this effect was not observed in women. Conclusions: Higher long-term SBP-TTR from childhood to midlife is associated with a reduced risk of arterial stiffness in midlife, regardless of the mean SBP or SBP variability. |
| format | Article |
| id | doaj-art-cf5f7779d9ed4882877f9c41c6491d2d |
| institution | Kabale University |
| issn | 2772-3747 |
| language | English |
| publishDate | 2025-01-01 |
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| series | JACC: Asia |
| spelling | doaj-art-cf5f7779d9ed4882877f9c41c6491d2d2025-01-09T06:14:56ZengElsevierJACC: Asia2772-37472025-01-0151101112Long-Term Time in Target Range for Systolic Blood Pressure Since Childhood and Midlife Arterial StiffnessYang Wang, MD, PhD0Han Qi, PhD1Hao Jia, MD2Dan Wang, MD3Yue Sun, MD4Bo-Wen Zhang, MPH5Ming-Fei Du, MD6Gui-Lin Hu, MD7Zi-Yue Man, MD8Chao Chu, MD, PhD9Xiao-Jun Yang, MPH10Teng Zhang, MD11Tong-Shuai Guo, MD12Xi Zhang, MD13Yu Yan, MD14Zheng Liu, PhD15Ming-Ke Chang, MD16Hao Li, MD17Fang-Yao Chen, PhD18Yu-Ming Kang, PhD19Jie Ren, MD20Zu-Yi Yuan, MD, PhD21Ling Zhang, PhD22Jian-Jun Mu, MD23Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Critical Care Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, ChinaDepartment of Physiology and Pathophysiology, Xi’an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China; Address for correspondence: Prof Ling Zhang, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, 10 Xitoutiao, Youanmenwai, Beijing 100069, China.Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China; Prof Jian-Jun Mu, Department of Cardiovascular Medicine, First Affiliated Hospital of Xian Jiaotong University, 277 Yanta West Road, Xi’an 710061, China.Background: Elevated blood pressure (BP) in childhood is associated with adult hypertension and arterial stiffness. However, the effect of long-term time in target range (TTR) for BP since childhood on the risk of arterial stiffness in midlife remains unclear. Objectives: The purpose of this study was to determine the independent association of TTR for systolic blood pressure (SBP) from childhood to midlife with arterial stiffness in adulthood. Methods: This study used data from the ongoing cohort of the Hanzhong Adolescent Hypertension Study. SBP-TTR was assessed over 36 years, with the target ranges of SBP defined as the 90th to 95th percentile of SBP for age, sex, and height in childhood, and 110 to 130 mm Hg in adulthood. Arterial stiffness was defined as brachial-ankle pulse wave velocity >1,400 cm/s. Results: Of the total 1,959 participants, 55.5% (1,088 of 1,959) were men, and the mean age was 49 years. The risk of arterial stiffness exhibited a gradual decrease with increasing SBP-TTR over the 36-year follow-up. Compared with the participants in the lowest quartile of SBP-TTR from childhood to midlife, those in the highest quartile showed significantly reduced arterial stiffness risk in midlife. This association persisted even after adjusting for mean SBP and SBP variability. Furthermore, men in the highest quartile of SBP-TTR demonstrated a markedly lower arterial stiffness risk than those in the lowest quartile, whereas this effect was not observed in women. Conclusions: Higher long-term SBP-TTR from childhood to midlife is associated with a reduced risk of arterial stiffness in midlife, regardless of the mean SBP or SBP variability.http://www.sciencedirect.com/science/article/pii/S2772374724004563arterial stiffnessblood pressureearly life courselongitudinal cohort studytime in target range |
| spellingShingle | Yang Wang, MD, PhD Han Qi, PhD Hao Jia, MD Dan Wang, MD Yue Sun, MD Bo-Wen Zhang, MPH Ming-Fei Du, MD Gui-Lin Hu, MD Zi-Yue Man, MD Chao Chu, MD, PhD Xiao-Jun Yang, MPH Teng Zhang, MD Tong-Shuai Guo, MD Xi Zhang, MD Yu Yan, MD Zheng Liu, PhD Ming-Ke Chang, MD Hao Li, MD Fang-Yao Chen, PhD Yu-Ming Kang, PhD Jie Ren, MD Zu-Yi Yuan, MD, PhD Ling Zhang, PhD Jian-Jun Mu, MD Long-Term Time in Target Range for Systolic Blood Pressure Since Childhood and Midlife Arterial Stiffness JACC: Asia arterial stiffness blood pressure early life course longitudinal cohort study time in target range |
| title | Long-Term Time in Target Range for Systolic Blood Pressure Since Childhood and Midlife Arterial Stiffness |
| title_full | Long-Term Time in Target Range for Systolic Blood Pressure Since Childhood and Midlife Arterial Stiffness |
| title_fullStr | Long-Term Time in Target Range for Systolic Blood Pressure Since Childhood and Midlife Arterial Stiffness |
| title_full_unstemmed | Long-Term Time in Target Range for Systolic Blood Pressure Since Childhood and Midlife Arterial Stiffness |
| title_short | Long-Term Time in Target Range for Systolic Blood Pressure Since Childhood and Midlife Arterial Stiffness |
| title_sort | long term time in target range for systolic blood pressure since childhood and midlife arterial stiffness |
| topic | arterial stiffness blood pressure early life course longitudinal cohort study time in target range |
| url | http://www.sciencedirect.com/science/article/pii/S2772374724004563 |
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