Expression patterns of TROP2 and Nectin-4 in oropharyngeal squamous cell carcinoma in relation to HPV status: potential biomarkers for targeted therapy

Expression patterns of TROP2 and Nectin-4 in oropharyngeal squamous cell carcinoma in relation to HPV status: potential biomarkers for targeted therapy

Background: Patients with inoperable or metastatic oropharyngeal squamous cell carcinoma (OSCC) face limited therapeutic options. Nectin-4, an immunoglobulin-like transmembrane adhesion protein, and Trophoblast Surface Antigen 2 (TROP2), a transmembrane glycoprotein, have recently emerged as targets...

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Main Authors: Charlotte Klasen, Hans N. C. Eckel, Nora Wuerdemann, Joseph Böckelmann, Karl Knipper, Malte Suchan, Kariem Sharaf, Shachi Jenny Sharma, Helen Abing, Arthur Charpentier, Julia Esser, Kevin Hansen, Marcel Mayer, Louis Jansen, Jens Peter Klußmann, Alexander Quaas, Su Ir Lyu
Format: Article
Language:English
Published: SAGE Publishing 2025-08-01
Series:Therapeutic Advances in Medical Oncology
Online Access:https://doi.org/10.1177/17588359251361877
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https://doi.org/10.1177/17588359251361877

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