A Systematic Review on Safety and Efficacy of Ayurvedic Interventions in Hemiplegia ()
The study's objective is to conduct a comprehensive systematic review for assessing the safety and efficacy of Ayurvedic interventions in managing hemiplegia/Pakshaghata. The study involved a search across multiple online databases and online clinical trial registries. Additionally, major Ayurv...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Journal of Evidence-Based Integrative Medicine |
| Online Access: | https://doi.org/10.1177/2515690X241304523 |
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| author | Akashlal M. MD (Ay) Pratibha P Nair MD (Ay) Devi R Nair MD (Ay) Azeem Ahmad MD (Ay) B Chandrasekhararao MD (Ay) D Sudhakar MD (Ay) Srikanth Narayanam PhD (Ay) Rabinarayan Acharya PhD (Ay) |
| author_facet | Akashlal M. MD (Ay) Pratibha P Nair MD (Ay) Devi R Nair MD (Ay) Azeem Ahmad MD (Ay) B Chandrasekhararao MD (Ay) D Sudhakar MD (Ay) Srikanth Narayanam PhD (Ay) Rabinarayan Acharya PhD (Ay) |
| author_sort | Akashlal M. MD (Ay) |
| collection | DOAJ |
| description | The study's objective is to conduct a comprehensive systematic review for assessing the safety and efficacy of Ayurvedic interventions in managing hemiplegia/Pakshaghata. The study involved a search across multiple online databases and online clinical trial registries. Additionally, major Ayurveda postgraduate institutes were contacted to acquire unpublished trial data related to hemiplegia/Pakshaghata. The review covered articles published until July 2023. Two reviewers independently performed data extraction and risk of bias assessment. The risk of bias assessment utilised the RoB 2 tool for randomised trials and the ROBINS-I tool for non-randomised trials. The screening process identified 28 articles from online databases and two dissertations from online repositories. However, practical challenges prevented access to grey literature from Ayurveda institutes. The 30 studies selected for this review, comprises nine randomised controlled trials (RCTs), eight non-randomised comparative trials, and thirteen pre-post studies. Quantitative analysis was unfeasible due to inadequate studies, leading to a qualitative analysis. All studies, except one, exhibited substantial bias upon risk of bias assessment. Moreover, most studies demonstrated methodological weaknesses attributed to a lack of masking, improper sampling techniques, non-validated outcome measurement tools, inadequate follow-up procedures, and confounding factors. The trials frequently did not document safety parameters, adverse events (AE), and adverse drug reactions (ADR). Current review could not definitively establish the efficacy and safety of Ayurvedic interventions in hemiplegia/Pakshaghata. Hence, the authors strongly advocate for good quality research incorporating proper methodology. |
| format | Article |
| id | doaj-art-ce9ffb74bf1442f08d19d8bab9866d74 |
| institution | Kabale University |
| issn | 2515-690X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Evidence-Based Integrative Medicine |
| spelling | doaj-art-ce9ffb74bf1442f08d19d8bab9866d742025-01-07T09:03:40ZengSAGE PublishingJournal of Evidence-Based Integrative Medicine2515-690X2025-01-013010.1177/2515690X241304523A Systematic Review on Safety and Efficacy of Ayurvedic Interventions in Hemiplegia ()Akashlal M. MD (Ay)0Pratibha P Nair MD (Ay)1Devi R Nair MD (Ay)2Azeem Ahmad MD (Ay)3B Chandrasekhararao MD (Ay)4D Sudhakar MD (Ay)5Srikanth Narayanam PhD (Ay)6Rabinarayan Acharya PhD (Ay)7 Department of Ayurveda, Regional Ayurveda Research Institute (CCRAS, M/O Ayush, Govt. India), Port Blair, Andaman & Nicobar Islands, India Department of Kayachikitsa, , Kottakkal, Kerala, India Department of Ayurveda, National Ayurveda Research Institute for Panchakarma (CCRAS, M/O Ayush, Govt. India), Cheruthuruthy, Kerala, India Department Ayurveda, , New Delhi, India Department Ayurveda, , New Delhi, India Department of Ayurveda, National Ayurveda Research Institute for Panchakarma (CCRAS, M/O Ayush, Govt. India), Cheruthuruthy, Kerala, India Department Ayurveda, , New Delhi, India Department Ayurveda, , New Delhi, IndiaThe study's objective is to conduct a comprehensive systematic review for assessing the safety and efficacy of Ayurvedic interventions in managing hemiplegia/Pakshaghata. The study involved a search across multiple online databases and online clinical trial registries. Additionally, major Ayurveda postgraduate institutes were contacted to acquire unpublished trial data related to hemiplegia/Pakshaghata. The review covered articles published until July 2023. Two reviewers independently performed data extraction and risk of bias assessment. The risk of bias assessment utilised the RoB 2 tool for randomised trials and the ROBINS-I tool for non-randomised trials. The screening process identified 28 articles from online databases and two dissertations from online repositories. However, practical challenges prevented access to grey literature from Ayurveda institutes. The 30 studies selected for this review, comprises nine randomised controlled trials (RCTs), eight non-randomised comparative trials, and thirteen pre-post studies. Quantitative analysis was unfeasible due to inadequate studies, leading to a qualitative analysis. All studies, except one, exhibited substantial bias upon risk of bias assessment. Moreover, most studies demonstrated methodological weaknesses attributed to a lack of masking, improper sampling techniques, non-validated outcome measurement tools, inadequate follow-up procedures, and confounding factors. The trials frequently did not document safety parameters, adverse events (AE), and adverse drug reactions (ADR). Current review could not definitively establish the efficacy and safety of Ayurvedic interventions in hemiplegia/Pakshaghata. Hence, the authors strongly advocate for good quality research incorporating proper methodology.https://doi.org/10.1177/2515690X241304523 |
| spellingShingle | Akashlal M. MD (Ay) Pratibha P Nair MD (Ay) Devi R Nair MD (Ay) Azeem Ahmad MD (Ay) B Chandrasekhararao MD (Ay) D Sudhakar MD (Ay) Srikanth Narayanam PhD (Ay) Rabinarayan Acharya PhD (Ay) A Systematic Review on Safety and Efficacy of Ayurvedic Interventions in Hemiplegia () Journal of Evidence-Based Integrative Medicine |
| title | A Systematic Review on Safety and Efficacy of Ayurvedic Interventions in Hemiplegia () |
| title_full | A Systematic Review on Safety and Efficacy of Ayurvedic Interventions in Hemiplegia () |
| title_fullStr | A Systematic Review on Safety and Efficacy of Ayurvedic Interventions in Hemiplegia () |
| title_full_unstemmed | A Systematic Review on Safety and Efficacy of Ayurvedic Interventions in Hemiplegia () |
| title_short | A Systematic Review on Safety and Efficacy of Ayurvedic Interventions in Hemiplegia () |
| title_sort | systematic review on safety and efficacy of ayurvedic interventions in hemiplegia |
| url | https://doi.org/10.1177/2515690X241304523 |
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