Quantitative 3D reconstruction of viral vector distribution in rodent and ovine brain following local delivery

Quantitative 3D reconstruction of viral vector distribution in rodent and ovine brain following local delivery

Viral vectors are an active area of research and development to treat diseases of the central nervous system (CNS). However, systemic delivery of large-molecular weight biologics is complicated by limited crossing of the blood-brain barrier, immunological clearance from the circulation, off-target e...

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Bibliographic Details
Main Authors: Roberta Poceviciute, Kenneth Mitchell, Angeliki Maria Nikolakopoulou, Suehyun K. Cho, Xiaobo Ma, Phillip Chen, Samantha Figueroa, Ethan J. Sarmiento, Aryan Singh, Oren Hartstein, William G. Loudon, Florent Cros, Alexander S. Kiselyov
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Neuroimage: Reports
Subjects:
Local drug delivery
Central nervous system
Gene therapy
Adeno-associated virus
Quantitative image analysis
3D reconstruction
Online Access:http://www.sciencedirect.com/science/article/pii/S2666956024000242
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