Identifying T-cell clubs by embracing the local harmony between TCR and gene expressions

Identifying T-cell clubs by embracing the local harmony between TCR and gene expressions

Abstract T cell receptors (TCR) and gene expression provide two complementary and essential aspects in T cell understanding, yet their diversity presents challenges in integrative analysis. We introduce TCRclub, a novel method integrating single-cell RNA sequencing data and single-cell TCR sequencin...

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Bibliographic Details
Main Authors: Yiping Zou, Jiaqi Luo, Lingxi Chen, Xueying Wang, Wei Liu, Ruo Han Wang, Shuai Cheng Li
Format: Article
Language:English
Published: Springer Nature 2024-11-01
Series:Molecular Systems Biology
Subjects:
Integration
Local Harmony
Single-Cell Analysis
T-Cell Clustering
Online Access:https://doi.org/10.1038/s44320-024-00070-5
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https://doi.org/10.1038/s44320-024-00070-5

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