Effect of metabolic syndrome on incidence of oral potentially malignant disorder: a prospective cohort study in Taiwan
Objectives We aimed to assess the effect of metabolic syndrome (MetS) on incident oral potentially malignant disorder (OPMD).Design We conducted a prospective cohort study of the Changhua community-based integrated screening (CHCIS) programme and nationwide oral cancer screening programme during the...
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BMJ Publishing Group
2020-10-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/10/e041971.full |
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| author | Yen-Po Yeh Tony Hsiu-Hsi Chen Li-Sheng Chen Amy Ming-Fang Yen Pallop Siewchaisakul Sen-Te Wang Szu-Min Peng Pongdech Sarakarn |
| author_facet | Yen-Po Yeh Tony Hsiu-Hsi Chen Li-Sheng Chen Amy Ming-Fang Yen Pallop Siewchaisakul Sen-Te Wang Szu-Min Peng Pongdech Sarakarn |
| author_sort | Yen-Po Yeh |
| collection | DOAJ |
| description | Objectives We aimed to assess the effect of metabolic syndrome (MetS) on incident oral potentially malignant disorder (OPMD).Design We conducted a prospective cohort study of the Changhua community-based integrated screening (CHCIS) programme and nationwide oral cancer screening programme during the period between 2005 and 2014.Setting CHCIS, Taiwan.Participants We enrolled 17 590 participants aged 30 years and older.Main outcomes and measures We assessed the impact of MetS on the outcome measured by incident OPMD.Results The incidences of OPMD among subjects with and without MetS were 7.68 ‰ and 5.38 ‰, respectively. After adjusting for confounders, subjects with MetS exhibited a statistically greater risk of developing OPMD compared with those who were free of MetS by 33% (adjusted rate ratio, aRR=1.33, 95% CI 1.14 to 1.55). Individual components of MetS still remained significant, including central obesity (aRR=1.22, 95% CI 1.04 to 1.44), hypertriglyceridaemia (aRR=1.26, 95% CI 1.07 to 1.49) and hyperglycaemia (aRR=1.20, 95% CI 1.02 to 1.41). Central obesity and hypertriglyceridaemia were also statistically associated with a subtype of OPMD, namely, leukoplakia.Conclusion The temporal influence of MetS on the risk of incident OPMD was noted in our prospective cohort study. Therefore, promoting an MetS prevention and control programme might reduce the occurrence of OPMD and oral cancer. |
| format | Article |
| id | doaj-art-cdd97f76b9254c03b286f935f9fb6651 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-cdd97f76b9254c03b286f935f9fb66512024-11-16T18:05:07ZengBMJ Publishing GroupBMJ Open2044-60552020-10-01101010.1136/bmjopen-2020-041971Effect of metabolic syndrome on incidence of oral potentially malignant disorder: a prospective cohort study in TaiwanYen-Po Yeh0Tony Hsiu-Hsi Chen1Li-Sheng Chen2Amy Ming-Fang Yen3Pallop Siewchaisakul4Sen-Te Wang5Szu-Min Peng6Pongdech Sarakarn7Changhua County Public Health Bureau, Changhua, TaiwanGraduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, TaiwanOral Health Care Research Center, College of Oral Medicine, Taipei Medical University, Taipei, TaiwanSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, TaiwanSchool of dentistry, College of Oral Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, TaiwanEpidemiology and Biostatistics Department, Faculty of Public Health, Khon Kaen University, Khon Kaen, ThailandObjectives We aimed to assess the effect of metabolic syndrome (MetS) on incident oral potentially malignant disorder (OPMD).Design We conducted a prospective cohort study of the Changhua community-based integrated screening (CHCIS) programme and nationwide oral cancer screening programme during the period between 2005 and 2014.Setting CHCIS, Taiwan.Participants We enrolled 17 590 participants aged 30 years and older.Main outcomes and measures We assessed the impact of MetS on the outcome measured by incident OPMD.Results The incidences of OPMD among subjects with and without MetS were 7.68 ‰ and 5.38 ‰, respectively. After adjusting for confounders, subjects with MetS exhibited a statistically greater risk of developing OPMD compared with those who were free of MetS by 33% (adjusted rate ratio, aRR=1.33, 95% CI 1.14 to 1.55). Individual components of MetS still remained significant, including central obesity (aRR=1.22, 95% CI 1.04 to 1.44), hypertriglyceridaemia (aRR=1.26, 95% CI 1.07 to 1.49) and hyperglycaemia (aRR=1.20, 95% CI 1.02 to 1.41). Central obesity and hypertriglyceridaemia were also statistically associated with a subtype of OPMD, namely, leukoplakia.Conclusion The temporal influence of MetS on the risk of incident OPMD was noted in our prospective cohort study. Therefore, promoting an MetS prevention and control programme might reduce the occurrence of OPMD and oral cancer.https://bmjopen.bmj.com/content/10/10/e041971.full |
| spellingShingle | Yen-Po Yeh Tony Hsiu-Hsi Chen Li-Sheng Chen Amy Ming-Fang Yen Pallop Siewchaisakul Sen-Te Wang Szu-Min Peng Pongdech Sarakarn Effect of metabolic syndrome on incidence of oral potentially malignant disorder: a prospective cohort study in Taiwan BMJ Open |
| title | Effect of metabolic syndrome on incidence of oral potentially malignant disorder: a prospective cohort study in Taiwan |
| title_full | Effect of metabolic syndrome on incidence of oral potentially malignant disorder: a prospective cohort study in Taiwan |
| title_fullStr | Effect of metabolic syndrome on incidence of oral potentially malignant disorder: a prospective cohort study in Taiwan |
| title_full_unstemmed | Effect of metabolic syndrome on incidence of oral potentially malignant disorder: a prospective cohort study in Taiwan |
| title_short | Effect of metabolic syndrome on incidence of oral potentially malignant disorder: a prospective cohort study in Taiwan |
| title_sort | effect of metabolic syndrome on incidence of oral potentially malignant disorder a prospective cohort study in taiwan |
| url | https://bmjopen.bmj.com/content/10/10/e041971.full |
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