Exercise alleviates hematopoietic stem cell injury following radiation via the carnosine/Slc15a2-p53 axis

Exercise alleviates hematopoietic stem cell injury following radiation via the carnosine/Slc15a2-p53 axis

Abstract Ionizing radiation (IR) can cause severe dysfunction of hematopoietic stem cells (HSCs), leading to acute or prolonged myelosuppression. In recent years, physical exercise has been recognized as a healthy lifestyle as it can fight a variety of diseases. However, whether it provides protecti...

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Main Authors: Hao Zeng, Naicheng Chen, Fang Chen, Xiaoyi Zhong, Lijing Yang, Yukai Lu, Mo Chen, Mingqiang Shen, Song Wang, Shilei Chen, Jia Cao, Xi Zhang, Jinghong Zhao, Yang Xu, Junping Wang, Mengjia Hu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell Communication and Signaling
Subjects:
Hematopoietic stem cell
Radiation
Exercise
Carnosine
p53 activity
Senescence
Online Access:https://doi.org/10.1186/s12964-024-01959-2
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https://doi.org/10.1186/s12964-024-01959-2

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