Clinical observation on Shenning mixture in treating IgA nephropathy
Objective To study the effect of Shenning mixture on mesangial proliferative IgA nephropathy.Methods Forty patients diagnosed as having mesangial proliferative IgA nephropathy by renal biopsy were randomly divided into two groups(observation group and control group).The patients in the observation g...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2016-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57919431&Fpath=home&index=0 |
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| Summary: | Objective To study the effect of Shenning mixture on mesangial proliferative IgA nephropathy.Methods Forty patients diagnosed as having mesangial proliferative IgA nephropathy by renal biopsy were randomly divided into two groups(observation group and control group).The patients in the observation group(n = 20) were given Shenning mixture,and those in the control group(n= 20) were given benazepril(10-20 mg/day).Symptomatic treatments were given in the two groups.After two months,the curative effectiveness was evaluated.Clinical remission was defined as 24 h urine volume of proteins ≤0.3 g with normal kidney functioa The significant effect was defined as proteinuria reduction of 50% or greater from baseline and normal kidney functioa The effect was defined as proteinuria reduction of 25%-50%,from baseline and normal kidney function.No effect was defined as none of above.The levels of hematuria,24 h urine protein quantity,blood Cys C,blood creatinine,blood urea nitrogen and the urine NAG enzyme were determined in two groups before and after treatment Results Three of the patients in the control group dropped out for headache and/or unbearable cough.All of the patients in the observation group finished the treatment There was no significant difference between two groups before treatment The 24 h urine protein quantity in observation group after the treatment was significantly reduced as compared with that before treatment[(0.8875 ± 0.2767) g vs.(1.6615 ± 0.1879) g,P<0.05].The 24 h urine protein quantitative in control group was reduced after treatment[(0.9871 ± 0.1385) g vs.(1.5160 ± 0.2290) g,P<0.05].No significant difference in 24 h urine protein quantity was observed in the two groups after the treatment No apparent change in the level of blood urea nitrogen and creatinine was observed after treatment in the two groups.Cys-C was reduced in the observation and control groups after therapy[control group:(0.870 ± 0.168) mg/L and(1.231 ±0.088) mg/L respectively,P<0.05;observation groups(0.829 ± 0.161) mg/L vs.(1.211 ± 0.108) mg/L,P<0.05 for both].There was no change of hematuria in the control groupa after treatment Hematuria was alleviated in the observation group after treatment[(50.47 ± 28.07) cell/μL vs.(189.39 ± 67.48) cells/μL,P<0.05].No significant change of urinary NAG enzyme was seen in the control group after treatment The level of NAG enzyme was decreased in the observation group after treatment[(25.1 ± 10.8) U/L vs.(14.35± 2.37) U/L,P<0.05].The total effective rate was 85.0% in observation group and 76.5% in control group.There was no significant difference in the effective rate between the two groups.Conclusions Shenning mixture and benazepril can reduce urinary protein volume,and alleviate early kidney damage.Shenning mixture can also improve hematuria and tubule function.Shenning mixture can be used to treat mesangial-proliferative IgA nephropathy. |
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| ISSN: | 1671-2390 |