Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods

Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods

In acute stroke, timely diagnosis is essential to prevent extensive neuronal damage and improve patient outcomes. However, differentiating between ischemic stroke, intracerebral hemorrhage, and stroke mimics remains challenging. Transfer RNA-derived fragments (tRFs) have emerged as potential biomark...

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Main Authors: Tamar Woudenberg, M. Leontien van der Bent, Daphne A.L. van den Homberg, T. Truc My Nguyen, Marieke J.H. Wermer, Ido R. van den Wijngaard, Paul H.A. Quax, A. Yaël Nossent, Nyika D. Kruyt
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Non-coding RNAs
tRNA-derived fragments
diagnostic biomarker
ischemic stroke
intracerebral hemorrhage
stroke mimic
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001076
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http://www.sciencedirect.com/science/article/pii/S2162253125001076

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