The Physiological Functions and Therapeutic Potential of Hypoxia-Inducible Factor-1α in Vascular Calcification

The Physiological Functions and Therapeutic Potential of Hypoxia-Inducible Factor-1α in Vascular Calcification

HIF-1α plays a crucial regulatory role in vascular calcification (VC), primarily influencing the osteogenic differentiation of VSMCs through oxygen-sensing mechanisms. Under hypoxic conditions, the stability of HIF-1α increases, avoiding PHD and VHL protein-mediated degradation, which promotes its a...

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Bibliographic Details
Main Authors: Zhenghong Zhang, Defan Wang, Renfeng Xu, Xiang Li, Zhengchao Wang, Yang Zhang
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomolecules
Subjects:
hypoxia-inducible factor-1α
vascular smooth muscle cell
energy metabolism
vascular calcification
therapeutic target
Online Access:https://www.mdpi.com/2218-273X/14/12/1592
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