Sestrin2 Attenuates Myocardial Endoplasmic Reticulum Stress and Cardiac Dysfunction During Ischemia/Reperfusion Injury

Sestrin2 Attenuates Myocardial Endoplasmic Reticulum Stress and Cardiac Dysfunction During Ischemia/Reperfusion Injury

Background Sesn2 (Sestrin2) is a stress‐induced protein that provides protective effects during myocardial ischemia and reperfusion (I/R) injury, while endoplasmic reticulum (ER) stress may be a pivotal mediator of I/R injury. The goal of this study was to determine whether Sesn2‐mTOR (mammalian tar...

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Bibliographic Details
Main Authors: Xuan Li, Zhen Wang, Alan J. Mouton, Ana C. M. Omoto, Alexandre A. da Silva, Jussara M. do Carmo, Ji Li, John E. Hall
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac injury
heart
mTOR signaling
unfolded protein response
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.035193
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