Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer

Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer

Abstract In colorectal cancer, oncogenic mutations transform a hierarchically organized and homeostatic epithelium into invasive cancer tissue lacking visible organization. We sought to define transcriptional states of colorectal cancer cells and signals controlling their development by performing s...

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Main Authors: Florian Uhlitz, Philip Bischoff, Stefan Peidli, Anja Sieber, Alexandra Trinks, Mareen Lüthen, Benedikt Obermayer, Eric Blanc, Yana Ruchiy, Thomas Sell, Soulafa Mamlouk, Roberto Arsie, Tzu‐Ting Wei, Kathleen Klotz‐Noack, Roland F Schwarz, Birgit Sawitzki, Carsten Kamphues, Dieter Beule, Markus Landthaler, Christine Sers, David Horst, Nils Blüthgen, Markus Morkel
Format: Article
Language:English
Published: Springer Nature 2021-08-01
Series:EMBO Molecular Medicine
Subjects:
cancer profiling
ERK
RNA velocity
single‐cell RNA sequencing
SLAM‐Seq
Online Access:https://doi.org/10.15252/emmm.202114123
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https://doi.org/10.15252/emmm.202114123

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