Reliable protein–protein docking with AlphaFold, Rosetta, and replica exchange

Despite the recent breakthrough of AlphaFold (AF) in the field of protein sequence-to-structure prediction, modeling protein interfaces and predicting protein complex structures remains challenging, especially when there is a significant conformational change in one or both binding partners. Prior s...

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Bibliographic Details
Main Authors: Ameya Harmalkar, Sergey Lyskov, Jeffrey J Gray
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/94029
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