Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers
Erythropoietin-producing hepatocellular (Eph) receptors comprise the largest group of surface receptors and are responsible for cellular signals. Eph/ephrin signaling has been identified to play a role in key cancer development and progression processes, especially in the upper gastrointestinal trac...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1520306/full |
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| author | Luccas Lavareze Luccas Lavareze Talita de Carvalho Kimura Talita de Carvalho Kimura João Figueira Scarini João Figueira Scarini Reydson Alcides de Lima-Souza Reydson Alcides de Lima-Souza Moisés Willian Aparecido Gonçalves Moisés Willian Aparecido Gonçalves Raisa Sales de Sá Raisa Sales de Sá Iara Gonçalves Aquino Iara Gonçalves Aquino Patricia Maria Fernandes Fernanda Cristina Poscai Ribeiro Albina Altemani Fernanda Viviane Mariano Gary Chris Fillmore Erika Said Abu Egal Erika Said Abu Egal |
| author_facet | Luccas Lavareze Luccas Lavareze Talita de Carvalho Kimura Talita de Carvalho Kimura João Figueira Scarini João Figueira Scarini Reydson Alcides de Lima-Souza Reydson Alcides de Lima-Souza Moisés Willian Aparecido Gonçalves Moisés Willian Aparecido Gonçalves Raisa Sales de Sá Raisa Sales de Sá Iara Gonçalves Aquino Iara Gonçalves Aquino Patricia Maria Fernandes Fernanda Cristina Poscai Ribeiro Albina Altemani Fernanda Viviane Mariano Gary Chris Fillmore Erika Said Abu Egal Erika Said Abu Egal |
| author_sort | Luccas Lavareze |
| collection | DOAJ |
| description | Erythropoietin-producing hepatocellular (Eph) receptors comprise the largest group of surface receptors and are responsible for cellular signals. Eph/ephrin signaling has been identified to play a role in key cancer development and progression processes, especially in the upper gastrointestinal tract. The Eph/ephrin system has been described as a tumor suppressor in duodenal cancer, while in esophageal, gastric, hepatic, and pancreatic cancer, the system has been related to tumor progression. For their significant role in developing a wide range of malignancies, Eph receptors and their ligands have proven to be an important target for new anticancer therapies. In this review, we present an overview of the literature and highlight evidence supporting the role of the Eph/ephrin system in upper digestive tract cancers. In addition, we discuss molecular findings that represent promising therapeutic targets for these cancers. |
| format | Article |
| id | doaj-art-cc4e074be1aa4e3b9436a82bc0aa940e |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-cc4e074be1aa4e3b9436a82bc0aa940e2025-01-07T05:23:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15203061520306Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancersLuccas Lavareze0Luccas Lavareze1Talita de Carvalho Kimura2Talita de Carvalho Kimura3João Figueira Scarini4João Figueira Scarini5Reydson Alcides de Lima-Souza6Reydson Alcides de Lima-Souza7Moisés Willian Aparecido Gonçalves8Moisés Willian Aparecido Gonçalves9Raisa Sales de Sá10Raisa Sales de Sá11Iara Gonçalves Aquino12Iara Gonçalves Aquino13Patricia Maria Fernandes14Fernanda Cristina Poscai Ribeiro15Albina Altemani16Fernanda Viviane Mariano17Gary Chris Fillmore18Erika Said Abu Egal19Erika Said Abu Egal20Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, BrazilDepartment of Internal Medicine, University of Western São Paulo (UNOESTE), Guarujá, São Paulo, BrazilDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, BrazilDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, BrazilBiorepository and Molecular Pathology, Huntsman Cancer Institute, University of Utah (UU), Salt Lake City, UT, United StatesDepartment of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, BrazilBiorepository and Molecular Pathology, Huntsman Cancer Institute, University of Utah (UU), Salt Lake City, UT, United StatesErythropoietin-producing hepatocellular (Eph) receptors comprise the largest group of surface receptors and are responsible for cellular signals. Eph/ephrin signaling has been identified to play a role in key cancer development and progression processes, especially in the upper gastrointestinal tract. The Eph/ephrin system has been described as a tumor suppressor in duodenal cancer, while in esophageal, gastric, hepatic, and pancreatic cancer, the system has been related to tumor progression. For their significant role in developing a wide range of malignancies, Eph receptors and their ligands have proven to be an important target for new anticancer therapies. In this review, we present an overview of the literature and highlight evidence supporting the role of the Eph/ephrin system in upper digestive tract cancers. In addition, we discuss molecular findings that represent promising therapeutic targets for these cancers.https://www.frontiersin.org/articles/10.3389/fonc.2024.1520306/fullEphgastric cancertarget therapyupper gastrointestinalephrin |
| spellingShingle | Luccas Lavareze Luccas Lavareze Talita de Carvalho Kimura Talita de Carvalho Kimura João Figueira Scarini João Figueira Scarini Reydson Alcides de Lima-Souza Reydson Alcides de Lima-Souza Moisés Willian Aparecido Gonçalves Moisés Willian Aparecido Gonçalves Raisa Sales de Sá Raisa Sales de Sá Iara Gonçalves Aquino Iara Gonçalves Aquino Patricia Maria Fernandes Fernanda Cristina Poscai Ribeiro Albina Altemani Fernanda Viviane Mariano Gary Chris Fillmore Erika Said Abu Egal Erika Said Abu Egal Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers Frontiers in Oncology Eph gastric cancer target therapy upper gastrointestinal ephrin |
| title | Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers |
| title_full | Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers |
| title_fullStr | Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers |
| title_full_unstemmed | Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers |
| title_short | Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers |
| title_sort | advances and current concepts on eph receptors and ephrins in upper digestive tract cancers |
| topic | Eph gastric cancer target therapy upper gastrointestinal ephrin |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1520306/full |
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