Machine learning and population pharmacokinetics: a hybrid approach for optimizing vancomycin therapy in sepsis patients

Machine learning and population pharmacokinetics: a hybrid approach for optimizing vancomycin therapy in sepsis patients

ABSTRACT Predicting vancomycin exposure is essential for optimizing dosing regimens in sepsis patients. While population pharmacokinetic (PPK) models are commonly used, their performance is limited. Machine learning (ML) models offer advantages over PPK models, but it remains unclear which model—PPK...

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Bibliographic Details
Main Authors: Keyu Chen, Chuhui Wang, Yu Wei, Sinan Ma, Weijia Huang, Yalin Dong, Yan Wang
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:Microbiology Spectrum
Subjects:
population pharmacokinetics
machine learning
sepsis
vancomycin
drug exposure
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00499-25
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https://journals.asm.org/doi/10.1128/spectrum.00499-25

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