Lack of biochemical signalling in GelMA leads to polarity reversion in intestinal organoids independent from mechanoreciprocity

Xenogeneic tumour origin and batch-to-batch variability of Engelbreth-Holm-Swarm sarcoma tumour cell-derived hydrogels (Matrigel, Cultrex) limit the biomedical application of organoids in tissue engineering. The gelatin-methacryloyl (GelMA) hydrogels represent a defined, tunable, and GMP-friendly al...

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Bibliographic Details
Main Authors: Lenie Vanhove, Thomas Van Gansbeke, Bert Devriendt, Ruben Van der Meeren, Ruslan I. Dmitriev, Irina A. Okkelman
Format: Article
Language:English
Published: SAGE Publishing 2025-06-01
Series:Journal of Tissue Engineering
Online Access:https://doi.org/10.1177/20417314251345000
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