The alphaherpesvirus gE/gI glycoprotein complex and proteases jointly orchestrate invasion across the host’s upper respiratory epithelial barrier

The alphaherpesvirus gE/gI glycoprotein complex and proteases jointly orchestrate invasion across the host’s upper respiratory epithelial barrier

ABSTRACT Alphaherpesviruses, including herpes simplex virus type 1 (HSV-1), pseudorabies virus (PRV), and bovine herpesvirus type 1 (BoHV-1), are significant pathogens affecting humans and animals. These viruses penetrate the upper respiratory tract mucosa, yet the mechanisms facilitating this invas...

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Main Authors: E. Van Crombrugge, X. Ren, S. Glorieux, I. Zarak, W. Van den Broeck, C. Bachert, N. Zhang, T. Van Zele, D. Kim, G. A. Smith, K. Laval, H. Nauwynck
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mBio
Subjects:
alphaherpesvirus
upper respiratory tract
pathogenesis, mucosa invasion
gE/gI complex
proteases
urokinase plasminogen activator
Online Access:https://journals.asm.org/doi/10.1128/mbio.01873-24
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https://journals.asm.org/doi/10.1128/mbio.01873-24

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