Metabolic reprogramming in hepatocellular carcinoma: an integrated omics study of lipid pathways and their diagnostic potential

Abstract Metabolic reprogramming is an important cancer hallmark. Recent studies have indicated that lipid metabolic reprogramming play a potential role in the development of hepatocellular carcinoma (HCC). However, the underlying mechanisms remain incompletely understood. In this study, we employed...

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Main Authors: Peng Dai, Jing Feng, Yanyan Dong, Shujing Zhang, Jianghong Cao, Xiaopeng Cui, Xueliang Qin, Shiming Yang, Daguang Fan
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
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Online Access:https://doi.org/10.1186/s12967-025-06698-7
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author Peng Dai
Jing Feng
Yanyan Dong
Shujing Zhang
Jianghong Cao
Xiaopeng Cui
Xueliang Qin
Shiming Yang
Daguang Fan
author_facet Peng Dai
Jing Feng
Yanyan Dong
Shujing Zhang
Jianghong Cao
Xiaopeng Cui
Xueliang Qin
Shiming Yang
Daguang Fan
author_sort Peng Dai
collection DOAJ
description Abstract Metabolic reprogramming is an important cancer hallmark. Recent studies have indicated that lipid metabolic reprogramming play a potential role in the development of hepatocellular carcinoma (HCC). However, the underlying mechanisms remain incompletely understood. In this study, we employed an integrated multi-omics approach, combining transcriptomic, proteomic, and metabolomic analyses, to explore the lipid metabolism pathways in HCC and evaluate their diagnostic potential. We collected ten pairs of HCC tissues (HCT) and adjacent non-tumor tissues (ANT) from patients undergoing surgical resection. Transcriptomic analysis identified 4,023 differentially expressed genes (DEGs) between HCT and ANT, with significant enrichment in lipid metabolism-related pathways, including fatty acid degradation and steroid hormone biosynthesis. Proteomic analysis revealed 2,531 differentially expressed proteins (DEPs), further highlighting lipid metabolism as a critical driver of HCC development. Metabolomic profiling identified 88 differentially expressed metabolites (DEMs), with notable alterations in lipid-related metabolites. Integrated analysis of transcriptomic, proteomic, and metabolomic data identified six key genes (LCAT, PEMT, ACSL1, GPD1, ACSL4, and LPCAT1) involved in lipid metabolism, which exhibited significant changes at both mRNA and protein levels and correlated strongly with lipid-related metabolites in HCT. Additionally, nine lipid-related metabolites were identified as potential diagnostic biomarkers for HCC, with six metabolites demonstrating high discriminative ability (AUC > 0.8) between HCT and ANT. Our findings provide new insights into the molecular mechanisms of lipid metabolism reprogramming in HCC, emphasize the critical role of lipid metabolism in its pathogenesis. The identification of lipid-related metabolites as potential diagnostic biomarkers holds significant promise for early detection and improved clinical management of HCC. The integrated multi-omics approach as a powerful tool for identifying novel biomarkers and therapeutic targets.
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spelling doaj-art-cbb7ba0af94e4130b274f93224d9d8f32025-08-20T03:45:32ZengBMCJournal of Translational Medicine1479-58762025-06-0123111710.1186/s12967-025-06698-7Metabolic reprogramming in hepatocellular carcinoma: an integrated omics study of lipid pathways and their diagnostic potentialPeng Dai0Jing Feng1Yanyan Dong2Shujing Zhang3Jianghong Cao4Xiaopeng Cui5Xueliang Qin6Shiming Yang7Daguang Fan8Department of Hepato-Pancreatic-Biliary Surgery, Shanxi Provincial People’s HospitalDepartment of Gastroenterology, Shanxi Provincial People’s HospitalDepartment of Pathology, Shanxi Provincial People’s HospitalDepartment of Digestive Endoscopy, Shanxi Provincial People’s HospitalDepartment of Medical Intensive Care Unit, Shanxi Provincial People’s HospitalDepartment of Hepato-Pancreatic-Biliary Surgery, Shanxi Provincial People’s HospitalDepartment of Hepato-Pancreatic-Biliary Surgery, Shanxi Provincial People’s HospitalDepartment of Hepato-Pancreatic-Biliary Surgery, Shanxi Provincial People’s HospitalDepartment of Hepato-Pancreatic-Biliary Surgery, Shanxi Provincial People’s HospitalAbstract Metabolic reprogramming is an important cancer hallmark. Recent studies have indicated that lipid metabolic reprogramming play a potential role in the development of hepatocellular carcinoma (HCC). However, the underlying mechanisms remain incompletely understood. In this study, we employed an integrated multi-omics approach, combining transcriptomic, proteomic, and metabolomic analyses, to explore the lipid metabolism pathways in HCC and evaluate their diagnostic potential. We collected ten pairs of HCC tissues (HCT) and adjacent non-tumor tissues (ANT) from patients undergoing surgical resection. Transcriptomic analysis identified 4,023 differentially expressed genes (DEGs) between HCT and ANT, with significant enrichment in lipid metabolism-related pathways, including fatty acid degradation and steroid hormone biosynthesis. Proteomic analysis revealed 2,531 differentially expressed proteins (DEPs), further highlighting lipid metabolism as a critical driver of HCC development. Metabolomic profiling identified 88 differentially expressed metabolites (DEMs), with notable alterations in lipid-related metabolites. Integrated analysis of transcriptomic, proteomic, and metabolomic data identified six key genes (LCAT, PEMT, ACSL1, GPD1, ACSL4, and LPCAT1) involved in lipid metabolism, which exhibited significant changes at both mRNA and protein levels and correlated strongly with lipid-related metabolites in HCT. Additionally, nine lipid-related metabolites were identified as potential diagnostic biomarkers for HCC, with six metabolites demonstrating high discriminative ability (AUC > 0.8) between HCT and ANT. Our findings provide new insights into the molecular mechanisms of lipid metabolism reprogramming in HCC, emphasize the critical role of lipid metabolism in its pathogenesis. The identification of lipid-related metabolites as potential diagnostic biomarkers holds significant promise for early detection and improved clinical management of HCC. The integrated multi-omics approach as a powerful tool for identifying novel biomarkers and therapeutic targets.https://doi.org/10.1186/s12967-025-06698-7Hepatocellular carcinoma (HCC)Lipid metabolismMetabolic reprogrammingMulti-omics analysisDiagnostic biomarkers
spellingShingle Peng Dai
Jing Feng
Yanyan Dong
Shujing Zhang
Jianghong Cao
Xiaopeng Cui
Xueliang Qin
Shiming Yang
Daguang Fan
Metabolic reprogramming in hepatocellular carcinoma: an integrated omics study of lipid pathways and their diagnostic potential
Journal of Translational Medicine
Hepatocellular carcinoma (HCC)
Lipid metabolism
Metabolic reprogramming
Multi-omics analysis
Diagnostic biomarkers
title Metabolic reprogramming in hepatocellular carcinoma: an integrated omics study of lipid pathways and their diagnostic potential
title_full Metabolic reprogramming in hepatocellular carcinoma: an integrated omics study of lipid pathways and their diagnostic potential
title_fullStr Metabolic reprogramming in hepatocellular carcinoma: an integrated omics study of lipid pathways and their diagnostic potential
title_full_unstemmed Metabolic reprogramming in hepatocellular carcinoma: an integrated omics study of lipid pathways and their diagnostic potential
title_short Metabolic reprogramming in hepatocellular carcinoma: an integrated omics study of lipid pathways and their diagnostic potential
title_sort metabolic reprogramming in hepatocellular carcinoma an integrated omics study of lipid pathways and their diagnostic potential
topic Hepatocellular carcinoma (HCC)
Lipid metabolism
Metabolic reprogramming
Multi-omics analysis
Diagnostic biomarkers
url https://doi.org/10.1186/s12967-025-06698-7
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