The role of AIM2 in inflammation and tumors
Absent in melanoma 2 (AIM2) serves as an intracellular nucleic acid sensor that predominantly detects double-stranded DNA (dsDNA) within the cells. This detection initiates the assembly of inflammasome and activates the inflammasome signaling cascade, resulting in the production of inflammatory medi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1466440/full |
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| author | Dalang Yu Siping Zheng Siping Zheng Lina Sui Lina Sui Yuling Xi Yuling Xi Tiansheng He Zhiping Liu |
| author_facet | Dalang Yu Siping Zheng Siping Zheng Lina Sui Lina Sui Yuling Xi Yuling Xi Tiansheng He Zhiping Liu |
| author_sort | Dalang Yu |
| collection | DOAJ |
| description | Absent in melanoma 2 (AIM2) serves as an intracellular nucleic acid sensor that predominantly detects double-stranded DNA (dsDNA) within the cells. This detection initiates the assembly of inflammasome and activates the inflammasome signaling cascade, resulting in the production of inflammatory mediators and the cleavage of Gasdermins. Consequently, these processes culminate in inflammatory responses and pyroptotic cell death. AIM2 plays a pivotal role in modulating inflammation and tumorigenesis, functioning through both inflammasome-dependent and independent mechanisms. Its influence on the host immune response is dual-faceted, exhibiting both promotive and inhibitory effects in the contexts of inflammation and tumors. These effects are predominantly contingent upon the specific cell type expressing AIM2 and the nature of the host’s disease. This article seeks to review the latest advancements in understanding the cell-specific functions of AIM2 in inflammation and tumorigenesis, with the objective of offering insights for further research on AIM2 and informing the development of targeted therapeutic strategies for clinical application. |
| format | Article |
| id | doaj-art-cbaa44d11aa34051a5fffe8b550240dd |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-cbaa44d11aa34051a5fffe8b550240dd2024-11-12T05:10:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-11-011510.3389/fimmu.2024.14664401466440The role of AIM2 in inflammation and tumorsDalang Yu0Siping Zheng1Siping Zheng2Lina Sui3Lina Sui4Yuling Xi5Yuling Xi6Tiansheng He7Zhiping Liu8School of Basic Medicine, Fuzhou Medical College of Nanchang University, Fuzhou, Jiangxi, ChinaSchool of Graduate, Gannan Medical University, Ganzhou, Jiangxi, ChinaSchool of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, ChinaSchool of Graduate, Gannan Medical University, Ganzhou, Jiangxi, ChinaSchool of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, ChinaSchool of Graduate, Gannan Medical University, Ganzhou, Jiangxi, ChinaSchool of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, ChinaSchool of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, ChinaSchool of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, ChinaAbsent in melanoma 2 (AIM2) serves as an intracellular nucleic acid sensor that predominantly detects double-stranded DNA (dsDNA) within the cells. This detection initiates the assembly of inflammasome and activates the inflammasome signaling cascade, resulting in the production of inflammatory mediators and the cleavage of Gasdermins. Consequently, these processes culminate in inflammatory responses and pyroptotic cell death. AIM2 plays a pivotal role in modulating inflammation and tumorigenesis, functioning through both inflammasome-dependent and independent mechanisms. Its influence on the host immune response is dual-faceted, exhibiting both promotive and inhibitory effects in the contexts of inflammation and tumors. These effects are predominantly contingent upon the specific cell type expressing AIM2 and the nature of the host’s disease. This article seeks to review the latest advancements in understanding the cell-specific functions of AIM2 in inflammation and tumorigenesis, with the objective of offering insights for further research on AIM2 and informing the development of targeted therapeutic strategies for clinical application.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1466440/fullAIM2inflammasomeinflammationtumorcytokine |
| spellingShingle | Dalang Yu Siping Zheng Siping Zheng Lina Sui Lina Sui Yuling Xi Yuling Xi Tiansheng He Zhiping Liu The role of AIM2 in inflammation and tumors Frontiers in Immunology AIM2 inflammasome inflammation tumor cytokine |
| title | The role of AIM2 in inflammation and tumors |
| title_full | The role of AIM2 in inflammation and tumors |
| title_fullStr | The role of AIM2 in inflammation and tumors |
| title_full_unstemmed | The role of AIM2 in inflammation and tumors |
| title_short | The role of AIM2 in inflammation and tumors |
| title_sort | role of aim2 in inflammation and tumors |
| topic | AIM2 inflammasome inflammation tumor cytokine |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1466440/full |
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